Results 151 to 160 of about 61,218 (243)

Rational Design of Nanobodies Targeting LINGO‐1

Applied Research, Volume 5, Issue 2, April 2026.
We rationally designed and recombinantly produced a panel of single‐domain antibodies (nanobodies) targeting the human transmembrane protein LINGO‐1, a key player in multiple sclerosis. ABSTRACT The leucine‐rich repeat and immunoglobulin‐like domain‐containing Nogo receptor‐interacting protein 1 (LINGO‐1) is a transmembrane protein expressed in neurons
Alexander Röntgen, Vaidehi Roy Chowdhury, Aubin Ramon, Matthew Greenig, Xing Xu, Pietro Sormanni, Michele Vendruscolo   +6 more
wiley   +1 more source

Glial Ion Channels in Myelin Pathophysiology: Insights from Leukodystrophies. [PDF]

Life (Basel)
Belfiore M, Visentin S, Ambrosini E.
europepmc   +1 more source

Evaluation of Brain Microstructural Alterations in Preschool Autism Spectrum Disorder: A Voxel‐Wise Multimodal MRI Study

Journal of Magnetic Resonance Imaging, Volume 63, Issue 4, Page 1053-1066, April 2026.
ABSTRACT Background Autism Spectrum Disorder (ASD) presents with early neurodevelopmental alterations in preschool children, yet comprehensive characterization using multimodal quantitative MRI remains limited in this age group. Purpose To investigate voxel‐wise brain microstructural differences in preschool ASD through integrated analysis of cerebral ...
Changhao Wang, Meiying Cheng, Yu Lu, Jinxia Guo, Xueyan Liu, Zhanqi Feng, Shipeng Liu, Xin Zhao   +7 more
wiley   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Klotho Function in Neurogenesis and Oligodendrogenesis: A Mini-Review Update. [PDF]

J Mol Neurosci
Possebom IR, Dos Santos GRO, Kawamoto EM.   +2 more
europepmc   +1 more source

Human CNTNAP1 Variants Associated With Severe Neurological Deficits: Additional Cases and Literature Review

Muscle &Nerve, Volume 73, Issue 4, Page 517-526, April 2026.
ABSTRACT CNTNAP1 encodes the Contactin‐Associated Protein 1 (CNTNAP1), also known as Caspr1, which is a transmembrane protein critical for nervous system function. CNTNAP1 is localized to the paranodal regions of all myelinated axons, flanking either side of the node of Ranvier.
Lacey B. Sell, Derek Garcia, Alexandra Hollá, Ilana Chilton, Seth DeVries, Ana María Gómez‐Moreno, Manuel Lubián‐Gutiérrez, Qian Shi, Manzoor A. Bhat   +8 more
wiley   +1 more source

Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor

NMR in Biomedicine, Volume 39, Issue 4, April 2026.
Children that undergo posterior fossa tumor resection may experience post‐surgery neurological symptoms related to disruption of the dentato‐rubro‐thalamic tract (DRTT). By comparing pre‐ and intraoperative diffusion MRI tractography, we observed more variation in microstructural measures in the DRTT near the resection cavity, which were more ...
Pien E. J. Jellema, Jannie P. Wijnen, Karina J. Kersbergen, Martijn Froeling, Maarten H. Lequin, Wouter P. Nieuwenhuis, Alberto De Luca, Eelco W. Hoving   +7 more
wiley   +1 more source

Aligned piezoelectric fibrous scaffolds for prevention of traumatic neuroma formation. [PDF]

Front Bioeng Biotechnol
Chen Y, Gu X, Zang H, Wang C, Li G.
europepmc   +1 more source

Electroactive Biodegradable Nerve Conduits Based on Alginate–Gelatine Polymer Matrix Modified With Inorganic Nanoparticles

Natural Sciences, Volume 6, Issue 2, April 2026.
The effects of ZnO, fullerene C60 and polyaniline (PANI) nanoparticles in hybrid nerve conduits are explored. The composites show enhanced electrical conductivity, permeability to physiological fluids and mechanical stability. The biocompatibility of composites is confirmed by in vivo and in vitro studies.
Liudmyla Sukhodub, Mariia Kumeda, Oleksandr Tsyndrenko, Natalia Bozhko, Liudmyla Vovchenko, Volodymyr Prokopiuk, Oleksander Petrenko, Leonid Sukhodub   +7 more
wiley   +1 more source