Results 151 to 160 of about 72,448 (306)

A Computational Investigation of Myelination and Epilepsy

Epilepsy, characterized by recurrent seizures, is one of the most prevalent neurological dis- eases worldwide. Recent advances suggest that myelination, the insulating sheaths around axons of neurons, plays a crucial role in the neuronal network’s ...
Dumas, Odin
core   +1 more source

Expanding Spectrum of FIG4‐Related Neurological Disorders of Lysosomal Homeostasis: Case Report and Overview of the Potential Genotype–Phenotype Correlations

Clinical Genetics, EarlyView.
FIG4 is essential for lysosomal homeostasis. FIG4‐related disorders present as a continuous spectrum from the juvenile lethality in Yunis‐Varon syndrome to an increased risk of amyotrophic lateral sclerosis (ALS) in adult life. FIG4‐related disorders comprise a novel group of disorders of lysosomal homeostasis and can be classified into severe ...
Pankaj Prasun, Matthew Rasberry
wiley   +1 more source

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients

Clinical Genetics, EarlyView.
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Camille Bergès, Clément Sauvestre, Sophie Naudion, Catherine Vincent Delorme, Thomas Smol, Mélanie Rama, Stephanie Moortgat, Isabelle Maystadt, Rogier Kersseboom, Martina Wilke, Stefan Barakat, Yoann Vial, Laurence Perrin, Sandrine Passemard, Farooq Ahmad, Muhammad Umair, Tobias Haack, Mona Grimmel, Alma Kuechler, Anne Slavotinek, Patrick Devine, Ugur Hodoglugil, Faisal Zafar, Erum Afzal, Tracy Dudding‐Byth, Guillaume Jouret, Lucas Herissant, Stephanie Efthymiou, Henry Houlden, Marine Legendre, Vincent Michaud   +30 more
wiley   +1 more source

SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism

Cell Proliferation, EarlyView.
This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang   +5 more
wiley   +1 more source

Control of Schwann Cell Myelination by DDR1 Receptor Tyrosine Kinase. [PDF]

Int J Mol Sci
Fan M, Sun Y, Mei R, Lu W, Zhao X, Yang A, Qiu M.   +6 more
europepmc   +1 more source

MYELIN CARBOHYDRATES [PDF]

Journal of Histochemistry & Cytochemistry, 1968
C W, Adams, O B, Bayliss
openaire   +2 more sources

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Predictive utility of a simple cranial magnetic resonance imaging score at term‐equivalent age for cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
This study evaluated the Total Abnormality Score (TAS) from cMRI at term‐equivalent age as a predictor of cerebral palsy (CP) in 137 infants born preterm or with low birthweight. Infants who developed CP had significantly higher TAS values (median 11 vs 2), with a TAS cut‐off of 9.5 demonstrating high sensitivity (88.9%) and specificity (91.4%) for CP ...
Anne‐Kathrin Dathe, Britta Maria Huening, Pia Deborah Weber, Uta Teschler, Maire Brasseler, Ursula Felderhoff‐Mueser, Monia Vanessa Dewan   +6 more
wiley   +1 more source

Human Schwann Cell-Derived Extracellular Vesicle Isolation, Bioactivity Assessment, and Omics Characterization

International Journal of Nanomedicine
Aisha Khan,1,2 Julia Oliveira,2 Yee-Shuan Lee,1 James D Guest,2,3 Risset Silvera,2 Yelena Pressman,2 Damien D Pearse,2,3 Adriana E Nettina,1,2 Pascal J Goldschmidt-Clermont,4 Hassan Al-Ali,2 Indigo Williams,2 Allan D Levi,2,3 W Dalton Dietrich2,3 ...
Khan A, Oliveira J, Lee YS, Guest JD, Silvera R, Pressman Y, Pearse DD, Nettina AE, Goldschmidt-Clermont PJ, Al-Ali H, Williams I, Levi AD, Dietrich WD   +12 more
doaj  

The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance. [PDF]

Hum Brain Mapp
Hayek D, Fernandes JH, Vockert N, Garcia-Garcia B, Mattern H, Behrenbruch N, Fischer L, Kalyani A, Doehler J, Hämmerer D, Yi YJ, Schreiber S, Maass A, Kuehn E.   +13 more
europepmc   +1 more source