Results 41 to 50 of about 1,098 (144)
Involvement of Kallikrein‐Related Peptidases in Normal and Pathologic Processes
Disease Markers, Volume 2015, Issue 1, 2015., 2015 Human kallikrein‐related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions. Their complex network of stimulatory and inhibitory interactions may induce inflammatory and immune responses and contribute to the ...
Ana Carolina B. Stefanini +4 more
wiley +1 more source
Biomarcadores salivares no cancro da cabeça e pescoço [PDF]
, 2022 Head and neck cancer (HNC) are a group of cancers which occur in the organs from the anatomical area referred. The HNC staging system is generalized for most subtypes of HNC and restricted for the seven classifying stages of this cancer, which affects ...
Rentroia, Mara Ivone Santos
core
Clinical and Translational Medicine, Volume 3, Issue 1, December 2014., 2014 Abstract Biomarker research is continuously expanding in the field of clinical proteomics. A combination of different proteomic–based methodologies can be applied depending on the specific clinical context of use. Moreover, current advancements in proteomic analytical platforms are leading to an expansion of biomarker candidates that can be identified.
Maria Frantzi +2 more
wiley +1 more source
A despecialization step underlying evolution of a family of serine proteases
, 2003 In the trypsin superfamily of serine proteases, non-trypsin-like primary specificities have arisen in only two monophyletic descendent subbranches. We have recreated an ancestor to one of these subbranches (granzyme) using phylogenetic inference, gene ...
Birktoft +37 more
core +1 more source
Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients [PDF]
, 2020 Background: The aetiologies and pathogeneses of the joint diseases rheumatoid arthritis (RA) and spondyloarthritis (SpA) are still not fully elucidated.
Bennike, Tue Bjerg +8 more
core +1 more source
Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
The Scientific World Journal, Volume 2014, Issue 1, 2014., 2014 Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment
Petra Hudler +4 more
wiley +1 more source
ビタミンD受容体アゴニストとしての胆汁酸およびその誘導体：分子メカニズムと生物学的作用 [PDF]
, 2018 筑波大学University of Tsukuba博士（生物科学）Doctor of Philosophy in Biological ...
193574 +2 more
core +2 more sources
A proteinase 3 contribution to juvenile idiopathic arthritis-associated cartilage damage [PDF]
, 2021 A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed.
Berard, Roberta A. +5 more
core +2 more sources
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression. [PDF]
, 2020 Current knowledge on the biology of squamous cell vulvar carcinoma (VSCC) is limited. We aimed to identify protein markers of VSCC tumors that would permit to stratify patients by progression risk.
Bakuła-Zalewska, Elwira +9 more
core +1 more source
Neutrophil‐derived Oxidants and Proteinases as Immunomodulatory Mediators in Inflammation
Mediators of Inflammation, Volume 3, Issue 4, Page 257-273, 1994., 1994 Neutrophils generate potent microbicidal molecules via the oxygen‐dependent pathway, leading to the generation of reactive oxygen intermediates (ROI), and via the non‐oxygen dependent pathway, consisting in the release of serine proteinases and metalloproteinases stored in granules.
V. Witko-Sarsat, B. Descamps-Latscha
wiley +1 more source