Results 1 to 10 of about 477,278 (318)

Socioeconomic cost of AML in Sweden—A population‐based study using multiple nation‐wide registers

eJHaem, 2021
Acute myeloid leukemia (AML) is associated with a high economic and clinical burden. Recently novel therapies have been added to standard treatment regimens. Here, we evaluated the economic impact of AML up until the introduction of these novel therapies.
Emma Hernlund, Josefine Redig, Björn Paulsson, Åsa Rangert Derolf, Martin Höglund, Simona Vertuani, Gunnar Juliusson   +6 more
doaj   +1 more source

The consequences of cohesin mutations in myeloid malignancies

Frontiers in Molecular Biosciences, 2023
Recurrent somatic mutations in the genes encoding the chromatin-regulatory cohesin complex and its modulators occur in a wide range of human malignancies including a high frequency in myeloid neoplasms. The cohesin complex has a ring-like structure which
Shubhra Ashish Bhattacharya, Shubhra Ashish Bhattacharya, Eve Dias, Eve Dias, Andrea Nieto-Aliseda, Marcus Buschbeck, Marcus Buschbeck   +6 more
doaj   +1 more source

Concurrent Evaluation of the Expression and Methylation of Secreted Frizzled-Related Protein 2 along with Beta-Catenin Expression in Patients with non-M3 Acute Myeloid Leukemia [PDF]

Iranian Journal of Medical Sciences, 2021
Background: Wnt signaling is a critical pathway for the development of acute myeloid leukemia (AML). Some studies have evaluated the expression or methylation of secreted frizzled-related protein 2 (SFRP2) as an antagonist and beta-catenin (β-catenin) as
Fatemeh Mirzaeyan, Bahram Chahardouli, Amin Mirzaeian, Nasrin Alizad Ghandforoush, Kamran Alimoghaddam, Shahrbano Rostami   +5 more
doaj   +1 more source

Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease

Frontiers in Immunology, 2023
The liver is a vital metabolic organ that also performs important immune-regulatory functions. In the context of infections, the liver represents a target site for various pathogens, while also having an outstanding capacity to filter the blood from ...
Mohamed Amer Musrati, Mohamed Amer Musrati, Patrick De Baetselier, Patrick De Baetselier, Kiavash Movahedi, Kiavash Movahedi, Kiavash Movahedi, Jo A. Van Ginderachter, Jo A. Van Ginderachter   +8 more
doaj   +1 more source

Conservative Management of Presumed Fetal Anemia Secondary to Maternal Chemotherapy for Acute Myeloid Leukemia

American Journal of Perinatology Reports, 2021
Acute myeloid leukemia occurs rarely during pregnancy. When it is diagnosed remote from term, treatment in the form of daunorubicin plus cytarabine induction with consolidative cytarabine is typically undertaken after the first trimester. There is little
Christina M. Nowik, Alina S. Gerrie, Jonathan Wong   +2 more
doaj   +1 more source

Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy

Frontiers in Immunology, 2020
Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and ...
Els Lebegge, Els Lebegge, Sana M. Arnouk, Sana M. Arnouk, Pauline M. R. Bardet, Pauline M. R. Bardet, Máté Kiss, Máté Kiss, Geert Raes, Geert Raes, Jo A. Van Ginderachter, Jo A. Van Ginderachter   +11 more
doaj   +1 more source

Age-related changes of the innate immune system of the palatine tonsil in a healthy cohort

Frontiers in Immunology, 2023
Although tonsillectomy is performed frequently, the role of palatine tonsils in life long immune protection or tolerance is still debated and the consequences of their removal for the immune system are of general interest.
Nico Andreas, Katharina Geißler, Juliane Priese, Orlando Guntinas-Lichius, Thomas Kamradt   +4 more
doaj   +1 more source

Systemic Reprogramming of Monocytes in Cancer

Frontiers in Oncology, 2020
Monocytes influence multiple aspects of tumor progression, including antitumor immunity, angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor-associated macrophages.
Máté Kiss, Máté Kiss, Aarushi Audhut Caro, Aarushi Audhut Caro, Geert Raes, Geert Raes, Damya Laoui, Damya Laoui   +7 more
doaj   +1 more source

High-Yield Human Induced Pluripotent Stem Cell-Derived Monocytes and Macrophages Are Functionally Comparable With Primary Cells

Frontiers in Cell and Developmental Biology, 2021
Macrophages are pivotal effectors of host immunity and regulators of tissue homeostasis. Understanding of human macrophage biology has been hampered by the lack of reliable and scalable models for cellular and genetic studies.
Di Cui, Alexandra Franz, Sophie A. Fillon, Linda Jannetti, Timo Isambert, Katrin Fundel-Clemens, Heinrich J. Huber, Coralie Viollet, Alexander Ghanem, Akira Niwa, Bernd Weigle, Stefan Pflanz, Stefan Pflanz   +12 more
doaj   +1 more source

Murine Liver Myeloid Cell Isolation Protocol

Bio-Protocol, 2015
In homeostasis, the liver is critical for the metabolism of nutrients including sugars, lipids, proteins and iron, for the clearance of toxins, and to induce immune tolerance to gut-derived antigens.
Benoit Stijlemans, Amanda Sparkes, Chloé Abels, Jiri Keirsse, Lea Brys, Yvon Elkrim, Patrick Baetselier, Alain Beschin, Jo Ginderachter   +8 more
doaj   +1 more source