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The prognostic impact of C‐reactive protein and albumin in patients diagnosed with acute myeloid leukaemia [PDF]
eJHaemBackground Acute myeloid leukaemia (AML) is an aggressive and heterogeneous malignant disease. Patient age, comorbidities and disease‐specific genetic abnormalities are recognized as primary determinants of treatment response.
Espen Talseth Skar +2 more
doaj +2 more sources
Socioeconomic cost of AML in Sweden—A population‐based study using multiple nation‐wide registers
eJHaem, 2021 Acute myeloid leukemia (AML) is associated with a high economic and clinical burden. Recently novel therapies have been added to standard treatment regimens. Here, we evaluated the economic impact of AML up until the introduction of these novel therapies.
Emma Hernlund +6 more
doaj +1 more source
Concurrent Evaluation of the Expression and Methylation of Secreted Frizzled-Related Protein 2 along with Beta-Catenin Expression in Patients with non-M3 Acute Myeloid Leukemia [PDF]
Iranian Journal of Medical Sciences, 2021 Background: Wnt signaling is a critical pathway for the development of acute myeloid leukemia (AML). Some studies have evaluated the expression or methylation of secreted frizzled-related protein 2 (SFRP2) as an antagonist and beta-catenin (β-catenin) as
Fatemeh Mirzaeyan +5 more
doaj +1 more source
The consequences of cohesin mutations in myeloid malignancies
Frontiers in Molecular Biosciences, 2023 Recurrent somatic mutations in the genes encoding the chromatin-regulatory cohesin complex and its modulators occur in a wide range of human malignancies including a high frequency in myeloid neoplasms. The cohesin complex has a ring-like structure which
Shubhra Ashish Bhattacharya +6 more
doaj +1 more source
Myeloid Derived Suppressor Cells in Chronic Myeloid Leukemia [PDF]
Frontiers in Oncology, 2015 The suppression of the immune system creates a permissive environment for development and progression of cancer. One population of immunosuppressive cells that have become the focus of intense study is myeloid derived suppressor cells (MDSCs), immature myeloid cells able to induce immune-escape, angiogenesis, and tumor progression.
Cesarina eGiallongo +7 more
openaire +6 more sources
Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
Frontiers in Immunology, 2023 The liver is a vital metabolic organ that also performs important immune-regulatory functions. In the context of infections, the liver represents a target site for various pathogens, while also having an outstanding capacity to filter the blood from ...
Mohamed Amer Musrati +8 more
doaj +1 more source
Haematologica, 2021 Cancer treatment is constantly evolving from a one-size-fits-all towards bespoke approaches for each patient. In certain solid cancers, including breast and lung, tumor genome profiling has been incorporated into therapeutic decision-making. For chronic
Vaidehi Krishnan +4 more
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Congenital leukemia cutis in an infant
Indian Journal of Paediatric Dermatology, 2022 Background: The infiltration of neoplastic leukocytes or their progenitors into the epidermis, dermis, or subcutis, resulting in clinically evident cutaneous lesions, is known as leukemia cutis.
Carol Lobo, J P Prathibha
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Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy
Frontiers in Immunology, 2020 Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and ...
Els Lebegge +11 more
doaj +1 more source
Systemic Reprogramming of Monocytes in Cancer
Frontiers in Oncology, 2020 Monocytes influence multiple aspects of tumor progression, including antitumor immunity, angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor-associated macrophages.
Máté Kiss +7 more
doaj +1 more source