Results 121 to 130 of about 3,692,716 (212)

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

Superantigens in Cancer Immunotherapy: Mechanisms, Engineering Strategies, and Therapeutic Potential

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Schematic overview of superantigen‐mediated antitumor immune responses and immune suppression within the tumor microenvironment. (1) Antigen‐presenting cells activate T cells through MHC‐II/TCR interactions resulting in the production of cytokines (2) The pro‐inflammatory cytokines released by activated immune cells stimulate downstream immune ...
Urooj Yousaf Virk, Hafiza Aasia Malik, Muneera Anwer, Jennifer Wilson, Md. Sifat Rahi, Ming Q. Wei   +5 more
wiley   +1 more source

Investigating the molecular basic of AMKL and MDS. [PDF]

, 2008
Malignant haematopoiesis is usually associated with various genetic lesions such as chromosomal translocations or mutations in individual genes. This thesis investigates the genetic basis of two such syndromes, acute megakaryoblastic leukaemia (AMKL) and
Salek-Ardakani, S.
core  

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Investigations of FLT3 internal tandem duplications in patients with acute myeloid leukaemia. [PDF]

, 2006
In acute myeloid leukaemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated an internal tandem duplication (ITD) in the FLT3 gene may adversely
Kottaridis, P.D., Kottaridis, Panagiotis
core  

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Characterisation of T cell defects in acute myeloid leukaemia [PDF]

, 2009
PhDUnderstanding the immune system in patients with cancer and how it interacts with malignant cells is critical for the development of successful immunotherapeutic strategies at a time when novel cancer treatment approaches are required.
Le Dieu, Helen Rifca
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, Volume 7, Issue 3, Page 99-108, September 2026.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

PRMT7‐mediated arginine methylation of FOXK activates Wnt/β‐catenin signalling to drive doxorubicin resistance in diffuse large B‐cell lymphoma

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
The high expression of PRMT7 enhances its interaction with DVL2 by methylating arginine residues on FOXK1/FOXK2. This process promotes the nuclear translocation of DVL2, thereby aberrantly activating the Wnt/β‐catenin signalling pathway, which ultimately drives the development of doxorubicin resistance in DLBCL.
Xiaoyan Zhao, Jiasi Zhang, Yao Teng, Yaqin Wang, Wen Yu, Yan Sun, Zhou Wu, Aiguo Liu   +7 more
wiley   +1 more source

Identification of Antileukemic Compound From Ginger by Integrating UHPLC–MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro and In Vivo Experimental Validation

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Metabolomic screening and UHPLC–MS verification identified Arctigenin as a candidate antileukemic compound from ginger. Multi‐dimensional computational and experimental validation demonstrated its anti‐AML activity through apoptosis induction and tumor growth suppression, with potential involvement of PARP1 and NFκB1.
Mengjun Huang, Jing Liu, Kaixuan Zeng, Lianling Xu, Yangchun Liu, Linyun Xie, Mengni Shi, Yan Zeng, Wenjun Liu, Ling Guo   +9 more
wiley   +1 more source