Results 11 to 20 of about 919,731 (432)
American Journal of Clinical Pathology, 2009 Myeloid sarcoma (MS), also termed extramedullary acute myeloid leukemia, extramedullary myeloid tumor, and granulocytic sarcoma or chloroma, is a rare manifestation that is characterized by the occurrence of 1 or more tumor myeloid masses occurring at an extramedullary site.
Campidelli C +3 more
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Ontogeny of Myeloid Cells [PDF]
Frontiers in Immunology, 2014 Granulocytes, monocytes, macrophages, and dendritic cells (DCs) represent a subgroup of leukocytes, collectively called myeloid cells. During the embryonic development of mammalians, myelopoiesis occurs in a stepwise fashion that begins in the yolk sac and ends up in the bone marrow (BM).
Ismé de Kleer +4 more
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Comprehensive methylome map of lineage commitment from haematopoietic progenitors. [PDF]
, 2010 Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged.
Aryee, Martin J +17 more
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Myeloid Derived Suppressor Cells in Chronic Myeloid Leukemia [PDF]
Frontiers in Oncology, 2015 The suppression of the immune system creates a permissive environment for development and progression of cancer. One population of immunosuppressive cells that have become the focus of intense study is myeloid derived suppressor cells (MDSCs), immature myeloid cells able to induce immune-escape, angiogenesis, and tumor progression.
Daniele Tibullo +7 more
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Myeloid malignancies and the microenvironment [PDF]
Blood, 2017 Abstract Research in the last few years has revealed a sophisticated interaction network between multiple bone marrow cells that regulate different hematopoietic stem cell (HSC) properties such as proliferation, differentiation, localization, and self-renewal during homeostasis.
Claudia Korn, Simón Méndez-Ferrer
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The consequences of cohesin mutations in myeloid malignancies
Frontiers in Molecular Biosciences, 2023 Recurrent somatic mutations in the genes encoding the chromatin-regulatory cohesin complex and its modulators occur in a wide range of human malignancies including a high frequency in myeloid neoplasms. The cohesin complex has a ring-like structure which
Shubhra Ashish Bhattacharya +6 more
doaj +1 more source
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
Nature reviews. Immunology, 2021 Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation of immune responses in many pathological conditions and are closely associated ...
F. Veglia, E. Sanseviero, D. Gabrilovich
semanticscholar +1 more source
EZH2 in Myeloid Malignancies [PDF]
Cells, 2020 Our understanding of the significance of epigenetic dysregulation in the pathogenesis of myeloid malignancies has greatly advanced in the past decade. Enhancer of Zeste Homolog 2 (EZH2) is the catalytic core component of the Polycomb Repressive Complex 2 (PRC2), which is responsible for gene silencing through trimethylation of H3K27. EZH2 dysregulation
Jenny Rinke +6 more
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Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
Frontiers in Immunology, 2023 The liver is a vital metabolic organ that also performs important immune-regulatory functions. In the context of infections, the liver represents a target site for various pathogens, while also having an outstanding capacity to filter the blood from ...
Mohamed Amer Musrati +8 more
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Haematologica, 2021 Cancer treatment is constantly evolving from a one-size-fits-all towards bespoke approaches for each patient. In certain solid cancers, including breast and lung, tumor genome profiling has been incorporated into therapeutic decision-making. For chronic
Vaidehi Krishnan +4 more
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