Results 11 to 20 of about 903,302 (304)
Methods in Molecular Biology, 2018 Advances in our understanding of the pathophysiology of acute myeloid leukemia (AML) have not yet led to major improvements in disease-free and overall survival of adults with this disease.
G. Ossenkoppele
semanticscholar +3 more sources
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]
Nature Communications, 2016 Myeloid-derived suppressor cells (MDSC) are a heterogeneous population expanded in cancer and other chronic inflammatory conditions. Here the authors identify the challenges and propose a set of minimal reporting guidelines for mouse and human MDSC ...
V. Bronte +14 more
semanticscholar +4 more sources
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. [PDF]
, 2010 Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged.
Aryee, Martin J +17 more
core +5 more sources
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
Nature reviews. Immunology, 2021 Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation of immune responses in many pathological conditions and are closely associated ...
F. Veglia, E. Sanseviero, D. Gabrilovich
semanticscholar +1 more source
Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
Frontiers in Immunology, 2023 The liver is a vital metabolic organ that also performs important immune-regulatory functions. In the context of infections, the liver represents a target site for various pathogens, while also having an outstanding capacity to filter the blood from ...
Mohamed Amer Musrati +8 more
doaj +1 more source
Haematologica, 2021 Cancer treatment is constantly evolving from a one-size-fits-all towards bespoke approaches for each patient. In certain solid cancers, including breast and lung, tumor genome profiling has been incorporated into therapeutic decision-making. For chronic
Vaidehi Krishnan +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Macrophages are pivotal effectors of host immunity and regulators of tissue homeostasis. Understanding of human macrophage biology has been hampered by the lack of reliable and scalable models for cellular and genetic studies.
Di Cui +12 more
doaj +1 more source
Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. [PDF]
, 2013 Lysophosphatidic acid (LPA) is a pleiotropic phospholipid present in the blood and certain tissues at high concentrations; its diverse effects are mediated through differential, tissue specific expression of LPA receptors.
Cardinal, Sofie +9 more
core +5 more sources
Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy
Frontiers in Immunology, 2020 Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and ...
Els Lebegge +11 more
doaj +1 more source
Blood, 2016 The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid ...
D. Arber +8 more
semanticscholar +1 more source