Results 21 to 30 of about 919,731 (432)
Frontiers in Cell and Developmental Biology, 2021 Macrophages are pivotal effectors of host immunity and regulators of tissue homeostasis. Understanding of human macrophage biology has been hampered by the lack of reliable and scalable models for cellular and genetic studies.
Di Cui +12 more
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Cutaneous myeloid sarcoma associated with chronic myeloid leukemia [PDF]
Anais Brasileiros de Dermatologia, 2017 Myeloid sarcoma is an extramedullary tumor of malignant myeloid cells often associated with acute myeloid leukemia, chronic myeloproliferative disorders and myelodysplastic syndromes. The skin is one of the most commonly affected sites. We report a rare case of cutaneous myeloid sarcoma associated with chronic myeloid leukemia.
Vasconcelos, Erica Rodrigues de Araujo +2 more
openaire +5 more sources
Nfix expression critically modulates early B lymphopoiesis and myelopoiesis [PDF]
, 2015 The commitment of stem and progenitor cells toward specific hematopoietic lineages is tightly controlled by a number of transcription factors that regulate differentiation programs via the expression of lineage restricting genes. Nuclear factor one (NFI)
Campos, Joana +5 more
core +6 more sources
Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy
Frontiers in Immunology, 2020 Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and ...
Els Lebegge +11 more
doaj +1 more source
Blood, 2016 The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid ...
D. Arber +8 more
semanticscholar +1 more source
HoxA9 binds and represses the Cebpa +8 kb enhancer [PDF]
, 2019 C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those
Aplan, Peter D. +7 more
core +2 more sources
Myeloid Cells and Lymphangiogenesis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 The lymphatic vascular system and the hematopoietic system are intimately connected in ontogeny and in physiology. During embryonic development, mammalian species derive a first lymphatic vascular plexus from the previously formed anterior cardinal vein, whereas birds and amphibians have a lymphatic vascular system of dual origin, composed of lymphatic
Zumsteg, Adrian, Christofori, Gerhard
openaire +4 more sources
Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia.
New England Journal of Medicine, 2020 BACKGROUND Older patients with acute myeloid leukemia (AML) have a dismal prognosis, even after treatment with a hypomethylating agent. Azacitidine added to venetoclax had promising efficacy in a previous phase 1b study.
C. Dinardo +29 more
semanticscholar +1 more source
Systemic Reprogramming of Monocytes in Cancer
Frontiers in Oncology, 2020 Monocytes influence multiple aspects of tumor progression, including antitumor immunity, angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor-associated macrophages.
Máté Kiss +7 more
doaj +1 more source
Immune cell census in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity [PDF]
, 2018 Aims: Atherosclerosis is characterised by the abundant infiltration of myeloid cells starting at early stages of disease. Myeloid cells are key players in vascular immunity during atherogenesis.
Ahern, David +8 more
core +1 more source