Results 21 to 30 of about 477,278 (318)

Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

eLife, 2020
Cancer immunotherapy by immune checkpoint blockade has proven its great potential by saving the lives of a proportion of late stage patients with immunogenic tumor types.
Ana Rita Pombo Antunes, Isabelle Scheyltjens, Johnny Duerinck, Bart Neyns, Kiavash Movahedi, Jo A Van Ginderachter   +5 more
doaj   +1 more source

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

Nature Communications, 2016
Dendritic cells are antigen-presenting cells consisting of distinct subsets originating from different lineages. Here, the authors identify the subsets of dendritic cells populating the tumour tissue in both mice and humans and find they have opposing ...
Damya Laoui, Jiri Keirsse, Yannick Morias, Eva Van Overmeire, Xenia Geeraerts, Yvon Elkrim, Mate Kiss, Evangelia Bolli, Qods Lahmar, Dorine Sichien, Jens Serneels, Charlotte L. Scott, Louis Boon, Patrick De Baetselier, Massimiliano Mazzone, Martin Guilliams, Jo A. Van Ginderachter   +16 more
doaj   +1 more source

Purification of Tumor-Associated Macrophages (TAM) and Tumor-Associated Dendritic Cells (TADC)

Bio-Protocol, 2014
Tumors are heterogeneous microenvironments where complex interactions take place between neoplastic cells and infiltrating inflammatory cells, such as tumor-associated macrophages (TAM) and tumor-associated dendritic cells (TADC).
Damya Laoui, Eva Overmeire, Jiri Keirsse, Kiavash Movahedi, Jo Ginderachter   +4 more
doaj   +1 more source

Macrophage Subsets in Obesity, Aligning the Liver and Adipose Tissue

Frontiers in Endocrinology, 2020
The increasing prevalence of obesity is accompanied by a rising incidence in metabolic syndrome and related pathologies such as non-alcoholic fatty liver disease. Macrophages are hypothesized to play central roles in these diseases, through their role as
Anneleen Remmerie, Anneleen Remmerie, Liesbet Martens, Liesbet Martens, Liesbet Martens, Charlotte L. Scott, Charlotte L. Scott   +6 more
doaj   +1 more source

Hematopoietic stem cells produce intermediate lineage adipocyte progenitors that simultaneously express both myeloid and mesenchymal lineage markers in adipose tissue

Adipocyte, 2021
Some adipocytes are produced from bone marrow hematopoietic stem cells. In vitro studies previously indicated that these bone marrow-derived adipocytes (BMDAs) were generated from adipose tissue macrophage (ATM) that lose their hematopoietic markers and ...
Kathleen M. Gavin, Timothy M. Sullivan, Joanne K. Maltzahn, Jeremy T. Rahkola, Alistair S. Acosta, Wendy M. Kohrt, Susan M. Majka, Dwight J. Klemm   +7 more
doaj   +1 more source

Molecular Measurable Residual Disease Testing of Blood During AML Cytotoxic Therapy for Early Prediction of Clinical Response

Frontiers in Oncology, 2019
Measurable residual disease (MRD) testing after initial chemotherapy treatment can predict relapse and survival in acute myeloid leukemia (AML). However, it has not been established if repeat molecular or genetic testing during chemotherapy can offer ...
Hong Yuen Wong, Anthony D. Sung, Katherine E. Lindblad, Sheenu Sheela, Gregory W. Roloff, David Rizzieri, Meghali Goswami, Matthew P. Mulé, Nestor R. Ramos, Jingrong Tang, Julie Thompson, Christin B. DeStefano, Kristi Romero, Laura W. Dillon, Dong-Yun Kim, Catherine Lai, Christopher S. Hourigan   +16 more
doaj   +1 more source

Congenital leukemia cutis in an infant

Indian Journal of Paediatric Dermatology, 2022
Background: The infiltration of neoplastic leukocytes or their progenitors into the epidermis, dermis, or subcutis, resulting in clinically evident cutaneous lesions, is known as leukemia cutis.
Carol Lobo, J P Prathibha
doaj   +1 more source

Diamonds in the Rough: Harnessing Tumor-Associated Myeloid Cells for Cancer Therapy

Frontiers in Immunology, 2018
Therapeutic approaches that engage immune cells to treat cancer are becoming increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid tumor types.
Emile J. Clappaert, Emile J. Clappaert, Aleksandar Murgaski, Aleksandar Murgaski, Helena Van Damme, Helena Van Damme, Mate Kiss, Mate Kiss, Damya Laoui, Damya Laoui   +9 more
doaj   +1 more source

Adoptive Transfer of Monocytes Sorted from Bone Marrow

Bio-Protocol, 2019
Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages (TAMs), M1-like TAMs
Damya Laoui, Eva Overmeire, Chloé Abels, Jiri Keirsse, Jo Ginderachter   +4 more
doaj   +1 more source

Pancreatic Myeloid Sarcoma [PDF]

Cureus, 2020
Myeloid sarcoma is an isolated extramedullary tumor mass consisting of immature myeloid cells. It is characterized by highly variable outcomes and usually disrupts the normal architecture of the normal tissue in which it originates. It may occur de novo or be associated with other hematological malignancies.
Nathaniel A Parker, Seth Joel Page, Ammar Al-Obaidi, Yasmine Hussein Agha, Hamzah Alqam   +4 more
openaire   +2 more sources