Results 171 to 180 of about 426,237 (354)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

open access: yesExploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu   +5 more
wiley   +1 more source

Phenylethanoid Glycosides in Cistanches: Chemistry, Pharmacokinetic, and Antitumor Properties

open access: yesFood Frontiers, EarlyView.
This review systematically summarizes the representative PhGs found in CH species, their pharmacokinetic parameters, and primary metabolites in humans and rats. Additionally, it examines the antitumor activities of PhGs in CH and their associated signaling pathways against various malignancies.
Jie Li   +7 more
wiley   +1 more source

High-dose cytosine arabinoside and mitoxantrone: a highly effective regimen in refractory acute myeloid leukemia [PDF]

open access: bronze, 1987
Wolfgang Hiddemann   +8 more
openalex   +1 more source

Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers

open access: yesIbrain, EarlyView.
This review highlights the potential of gold nanoparticles (AuNPs) in overcoming the blood‐brain barrier (BBB) to improve brain tumor treatment. By enabling targeted drug delivery and enhancing therapies like radiotherapy, phototherapy, and chemotherapy, AuNPs offer a promising approach for safer, more effective treatments of glioblastoma and other ...
Simona Tarantino   +4 more
wiley   +1 more source

The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. [PDF]

open access: green, 1987
Michelle M. Le Beau   +6 more
openalex   +1 more source

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