Results 201 to 210 of about 414,323 (331)

Hidden Insights: Comprehensive Radiological Analysis of Four Skeletal Populations From 13th–19th Century Southern Finland Reveals Neoplastic and Other Lesions Invisible on Bone Surfaces

open access: yesInternational Journal of Osteoarchaeology, EarlyView.
ABSTRACT This study aims to identify lesions confined to the internal structures of bones. A radiographic analysis was performed on 219 archaeological, historical period skeletons from southern Finland. Although the study examines nearly all preserved skeletal elements using plain radiographs, it does not incorporate computed tomography.
Kati Salo   +2 more
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

Supplementary Spreadsheet S7 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma

open access: gold
Eileen M. Boyle   +27 more
openalex   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

open access: yesPM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang   +6 more
wiley   +1 more source

Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review

open access: yesRare Metals, EarlyView.
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu   +12 more
wiley   +1 more source

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