Results 101 to 110 of about 119,702 (326)

DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study

Annals of Neurology, EarlyView.
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito, P. Calleja, L. Alzamora, A. Ruiz‐García, A. Martínez‐Salio, M. Muñoz‐García, F. Ostos, A. García‐Culebras, A. Moraga, M.A. Moro, I. Lizasoain   +10 more
wiley   +1 more source

Eugenol Inhibits Neutrophils Myeloperoxidase In Vitro and Attenuates LPS-Induced Lung Inflammation in Mice

Pharmaceuticals
Eugenol (Eug) is a polyphenol extracted from the essential oil of Syzygium aromaticum (L.) Merr. and Perry (Myrtaceae). The health benefits of eugenol in human diseases were proved in several studies.
Amina Chniguir, Mohamed Hedi Saguem, Pham My-Chan Dang, Jamel El-Benna, Rafik Bachoual   +4 more
doaj   +1 more source

Protection by 20-5,14-HEDGE Against Surgically-Induced Ischemia Reperfusion Lung Injury in Rats [PDF]

, 2012
Background We previously reported that the cytochrome P450 product 20-hydroxyeicosatetraenoic acid has prosurvival effects in pulmonary artery endothelial cells and ex vivo pulmonary arteries.
Ali, Irshad, Clough, Anne V., Falck, John R., Gao, Ying, Gruenloh, Stephanie, Jacobs, Elizabeth R., Medhora, Meetha   +6 more
core   +2 more sources

Assessment of myeloperoxidase (Mpo) gene polymorphism in cervical cancer

, 2022
Yasemen Adalı, Sacide Pehlıvan, Sibel Oğuzkan Balcı, Meral Koyuncuoğlu   +3 more
openalex   +2 more sources

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Dysbiosis by neutralizing commensal mediated inhibition of pathobionts [PDF]

, 2016
Dysbiosis in the periodontal microbiota is associated with the development of periodontal diseases. Little is known about the initiation of dysbiosis.
Bernaerts, Kristel, Boon, Nico, Hernandez Sanabria, Emma, Herrero, Esteban Rodriguez, Quirynen, Marc, Slomka, Vera, Teughels, Wim   +6 more
core   +3 more sources

Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal

Journal of Lipid Research, 2010
Neutrophils are important in the host response against invading pathogens. One chemical defense mechanism employed by neutrophils involves the production of myeloperoxidase (MPO)-derived HOCl.
Dhanalakshmi S. Anbukumar, Laurie P. Shornick, Carolyn J. Albert, Melissa M. Steward, Raphael A. Zoeller, William L. Neumann, David A. Ford   +6 more
doaj   +1 more source

Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. [PDF]

, 2014
Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus ...
Butcher, Brad, Carlson, Adam Q, Graf, Jonathan, Imboden, John B, Jen, Kuang-Yu, Sam, Ramin, Tuot, Delphine S   +6 more
core   +2 more sources

Systemic immune‑inflammation index predicts a reduced risk of end‑stage renal disease in Chinese patients with myeloperoxidase‑anti‑neutrophil cytoplasmic antibody‑associated vasculitis: A retrospective observational study

, 2021
Jinbiao Chen, Rong Tang, Yong Zhong, Yaou Zhou, Xiaoxia Zuo, Hui Luo, Li Huang, Wei Lin, Ting Wu, Yingqiang Yang, Ting Meng, Zhou Xiao, Xiang Ao, Xiangcheng Xiao, Qiaoling Zhou, Ping Xiao   +15 more
openalex   +2 more sources

Risk factors for relapse in ANCA‐associated vasculitis among patients with relapse after induction of remission with rituximab

Arthritis &Rheumatology, Accepted Article.
Objective To determine risk factors for relapse of ANCA‐associated vasculitis (AAV) after re‐induction of remission with rituximab and discontinuation of maintenance therapy. Methods This is a post‐hoc analysis of the RITAZAREM clinical trial. Patients 15 years or older with AAV and a positive test for anti‐proteinase‐3 (PR3‐) or anti‐myeloperoxidase ...
Ellen Romich, Joshua F. Baker, Thomas R. Riley IV, Ian Green, Rennie L. Rhee, Carol A. McAlear, Ulrich Specks, Rona M. Smith, David R. Jayne, Peter A. Merkel, for the RITAZAREM Investigators   +10 more
wiley   +1 more source