Results 11 to 20 of about 145,768 (387)
Pulmonary Myeloperoxidase Activity [PDF]
Bio-Protocol, 2013 Neutrophils are considered one of the first responders of the innate immune response. Their primary activities are to migrate to sites of infection by chemotaxis and trans-migration across the endothelium (Gaines et al., 2005).
Tammy Ozment
doaj +4 more sources
Myeloperoxidase: friend and foe [PDF]
Journal of Leukocyte Biology, 2005 AbstractNeutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their primary function, the phagocytosis and destruction of microorganisms. When coated with opsonins (generally complement and/or antibody), microorganisms bind to specific receptors on the surface of the phagocyte and invagination of the cell membrane occurs ...
S. Klebanoff
semanticscholar +4 more sources
Biosynthesis of human myeloperoxidase.
Archives of Biochemistry and Biophysics, 2018 Members of Chordata peroxidase subfamily [1] expressed in mammals, including myeloperoxidase (MPO), eosinophil peroxidase (EPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO), express conserved motifs around the heme prosthetic group essential for their activity, a calcium-binding site, and at least two covalent bonds linking the heme group to ...
W. Nauseef
semanticscholar +5 more sources
Acta Neuropathologica Communications, 2022 Introduction Neutrophil accumulation is a well-established feature of Alzheimer’s disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory and vascular pathways.
Leon C. D. Smyth +18 more
semanticscholar +1 more source
Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy
Antioxidants, 2022 Neutrophils, the most abundant white blood cells in humans, are critical for host defense against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils can eradicate bacteria and clear debris.
Salma A Rizo-Téllez +2 more
semanticscholar +1 more source
Role of myeloperoxidase in inflammation and atherosclerosis (Review)
Biomedical Reports, 2022 Myeloperoxidase (MPO) belongs to the heme peroxidase family, which includes a set of enzymes with potent oxidoreductase activity. MPO is considered an important part of the innate immune system's microbicidal arm and is secreted by neutrophils and ...
Christian Frangie, J. Daher
semanticscholar +1 more source
The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication
Antioxidants, 2021 Myeloperoxidase is a signature enzyme of polymorphonuclear neutrophils in mice and humans. Being a component of circulating white blood cells, myeloperoxidase plays multiple roles in various organs and tissues and facilitates their crosstalk.
Yulia Kargapolova +5 more
semanticscholar +1 more source
The role of myeloperoxidase (MPO) in biomolecule modification, chronic inflammation and disease.
Antioxidants and Redox Signaling, 2020 SIGNIFICANCE Release of myeloperoxidase (MPO) by activated leukocytes is critical in innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong oxidants, which kill bacteria and other invading pathogens.
Michael Davies, C. Hawkins
semanticscholar +1 more source
Myeloperoxidase in kidney disease [PDF]
Kidney International, 2003 In glomerular and tubulointerstitial disease, polymorphonuclear- and monocyte-derived reactive oxygen species may contribute to oxidative modification of proteins, lipids, and nucleic acids. In part, the processes instigated by reactive oxygen species parallel events that lead to the development of atherosclerosis. Myeloperoxidase (MPO), a heme protein
Ernst Malle +4 more
openaire +2 more sources
Myeloperoxidase in Health and Disease
International Journal of Molecular Sciences, 2023 Innate and adaptive immune responses comprise a complex network of protein–protein and protein–cell interactions that regulates commensal flora and protects organisms from foreign pathogens and transformed (proliferating) host cells under physiological conditions such as pregnancy, growth and development as well as formulating a response pathological ...
Tamara Ortiz-Cerda +3 more
openaire +3 more sources