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Biochemical and Biophysical Research Communications, 1980
Summary The optical spectrum of the primary peroxide compound of myeloperoxidase (compound I) is reported. The spectrum, obtained in 1 msec after mixing native ferric myeloperoxidase with excess hydrogen peroxide, exhibits a Soret maximum at 425 nm (c = 52 mM−1 cm−1) and an increase in extinction of the ferric peroxidase at wavelengths higher than ...
J E, Harrison +3 more
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Summary The optical spectrum of the primary peroxide compound of myeloperoxidase (compound I) is reported. The spectrum, obtained in 1 msec after mixing native ferric myeloperoxidase with excess hydrogen peroxide, exhibits a Soret maximum at 425 nm (c = 52 mM−1 cm−1) and an increase in extinction of the ferric peroxidase at wavelengths higher than ...
J E, Harrison +3 more
openaire +2 more sources
Myeloperoxidase in Cardiovascular Disease
2013Myeloperoxidase (MPO) plays a central role in the innate immune system by generating leukocyte-derived oxidants to combat invading pathogens. These reactive intermediates have been increasingly recognized to be potentially deleterious, causing oxidative injury in inflammatory disease states such as cardiovascular disease.
Robert A, Koeth +2 more
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The development of myeloperoxidase inhibitors
Bioorganic & Medicinal Chemistry Letters, 2019Myeloperoxidase (MPO), an abundant hemoprotein present in neutrophils and monocytes, plays a significant role in immune surveillance and host defense mechanisms. However, increased MPO activity has been linked to a number of pathologies with compelling evidence in initiation and progression of inflammatory events.
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Myeloperoxidase: Growing Importance in Cancer Pathogenesis and Potential Drug Target
Pharmacology & Therapeutics, 2022Julia Kargl +2 more
exaly
Human myeloperoxidase and hemi-myeloperoxidase.
Methods in enzymology, 1987P C, Andrews, N I, Krinsky
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