Results 11 to 20 of about 32,127 (239)
Myelodysplastic/Myeloproliferative Neoplasms [PDF]
American Journal of Clinical Pathology, 2009 AbstractMyelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are rare de novo myeloid neoplasms that exhibit hybrid dysplastic and proliferative features at presentation. This SHP/EAHP Workshop session was uniquely problematic owing to the overlap between MDS/MPNs and both chronic myeloproliferative neoplasms and myelodysplasia.
Kathryn Foucar
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Deactylase inhibition in myeloproliferative neoplasms [PDF]
Investigational New Drugs, 2010 Myeloproliferative neoplasms (MPN) are clonal haemopoietic progenitor cell disorders characterized by the proliferation of one or more of the haemopoietic lineages (myeloid, erythroid and/or megakaryocytic). The MPNs include eight haematological disorders: chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET ...
Tiffany Khong +4 more
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Myeloproliferative neoplasms cause glomerulopathy [PDF]
Kidney International, 2011 Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. To better characterize the glomerular disease associated with myeloproliferative neoplasms, we evaluated features of 11 patients with myeloproliferative neoplasm-related glomerulopathy that included 8 patients with primary ...
Samar M. Said +9 more
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Genetics of Myeloproliferative Neoplasms
Hematology/Oncology Clinics of North America, 2021 Myeloproliferative neoplasms are hematopoietic stem cell disorders based on somatic mutations in JAK2, calreticulin, or MPL activating JAK-STAT signaling. Modern sequencing efforts have revealed the genomic landscape of myeloproliferative neoplasms with additional genetic alterations mainly in epigenetic modifiers and splicing factors.
Szybinski, Jakub, Meyer, Sara C.
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Epigenetics in Myeloproliferative Neoplasms [PDF]
Journal of Cellular and Molecular Medicine, 2017 AbstractA decade on from the description of JAK2 V617F, the MPNs are circumscribed by an increasingly intricate landscape. There is now evidence that they are likely the result of combined genetic dysregulation, with several mutated genes involved in the regulation of epigenetic mechanisms. Epigenetic changes are not due to a change in the DNA sequence
Suzanne McPherson +2 more
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Genomics of Myeloproliferative Neoplasms [PDF]
Journal of Clinical Oncology, 2017 Myeloproliferative neoplasms (MPNs) are a group of related clonal hematologic disorders characterized by excess accumulation of one or more myeloid cell lineages and a tendency to transform to acute myeloid leukemia. Deregulated JAK2 signaling has emerged as the central phenotypic driver of BCR -ABL1–negative MPNs and a unifying therapeutic target. In
Zoi, Katerina, Cross, Nicholas
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Severe Dizziness and Hypereosinophilia: Coincidence or Complication? A Case Report
Case Reports in Oncology, 2020 Hypereosinophilia is a common issue in medicine. One rare cause is myeloproliferative neoplasm with PDGFRA rearrangement. In these patients, the gold standard for therapy is low-dose imatinib.
Giorgia Lo Presti +4 more
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eJHaem, 2022 This report highlights the value of flow cytometry analysis, particularly in the setting of myeloproliferative neoplasms showing features of progression, as neoplastic plasmacytoid dendritic cell (PDC) proliferations may be present, representing either a
Siba El Hussein +11 more
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Haematologica, 2019 Distinguishing essential thrombocythemia JAK2V617F from polycythemia vera is difficult because of shared mutation and phenotypic characteristics. The World Health Organization suggested hemoglobin and hematocrit values to diagnose polycythemia vera (PV),
Richard T. Silver, Spencer Krichevsky
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SAGE Open Medical Case Reports, 2021 The entity myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome is characterized by the coexistence of both myeloproliferative and myelodysplastic features in the bone marrow.
Anette Lodvir Hemsing +4 more
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