Results 111 to 120 of about 44,049 (225)

Pre‐RAI Monocyte‐to‐Lymphocyte Ratio Predicts Early and Higher Recurrence Risk in Intermediate‐Risk DTC, While PNI and NRI Show No Prognostic Value

Clinical Endocrinology, Volume 104, Issue 6, Page 670-681, June 2026.
ABSTRACT Objective Differentiated thyroid carcinoma (DTC) has an excellent prognosis, but recurrence remains a clinical concern, especially in intermediate‐risk patients. Current stratification systems focus primarily on tumor characteristics, overlooking the host's biological capacity to counteract tumor progression.
Tommaso Piticchio, Francesco Galeano, Salvatore Volpe, Antonio Prinzi, Ignazio Barca, Andrea Scuto, Rosario Le Moli, Giulio Geraci, Andrea Tumminia, Sium Wolde Sellasie, Francesco Pallotti, Francesco Frasca   +11 more
wiley   +1 more source

Mutations and thrombosis in essential thrombocythemia

Blood Cancer Journal, 2021
Paola Guglielmelli, Naseema Gangat, Giacomo Coltro, Terra L. Lasho, Giuseppe Gaetano Loscocco, Christy M. Finke, Erika Morsia, Benedetta Sordi, Natasha Szuber, Curtis A. Hanson, Animesh Pardanani, Alessandro M. Vannucchi, Ayalew Tefferi   +12 more
doaj   +1 more source

A single JAK2‐V617F hematopoietic stem cell can initiate myeloproliferative neoplasm when transplanted into non‐conditioned recipient mice

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells (HSCs) that are most frequently caused by acquired somatic mutations in JAK2. A number of conditional mouse models of JAK2‐V617F‐driven MPN have been generated that rely on Cre‐LoxP‐mediated activation, resulting in polyclonal disease.
Quentin Kimmerlin, Morgane Hilpert, Nils Hansen, Alexandre Guy, Marc Usart, Jan Stetka, Patryk Sobieralski, Tiago Almeida Fonseca, Hui Hao‐Shen, Radek C. Skoda   +9 more
wiley   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Phenotypical differences and thrombosis rates in secondary erythrocytosis versus polycythemia vera

Blood Cancer Journal, 2021
Eliane Nguyen, Michaël Harnois, Lambert Busque, Shireen Sirhan, Sarit Assouline, Ines Chamaki, Harold Olney, Luigina Mollica, Natasha Szuber   +8 more
doaj   +1 more source

The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies

Balkan Medical Journal, 2019
The introduction and advances on next-generation sequencing have led to novel ways to integrate simultaneous assessment of multiple target genes in routine laboratory analysis.
Fulya Öz Puyan, Serhan Alkan
doaj   +1 more source

CALR/HIF‐1α Positive Feedback Loop Drives CALR Upregulation to Promote EMT‐Mediated Bladder Cancer Progression via ROS/AKT Axis

Cancer Science, Volume 117, Issue 5, Page 1286-1302, May 2026.
This study first found that the high expression of CALR is due to a novel positive feedback loop with HIF‐1α in the tumor microenvironment: CALR stabilizes HIF‐1α protein, while HIF‐1α transcriptionally upregulates CALR expression, thereby self‐sustaining its high expression levels in BLCA.
Xintao Tian, Yue Liu, Zhiyuan Mi, Ye Liang, Zhao Zhang, Xiaocheng Ma, Huiqing Jia, Yuxuan Cao, Zhijuan Liang, Shaonan Yang, Guofeng Ma, Haitao Niu   +11 more
wiley   +1 more source

Neutralize the neutrophils! Neutrophil β1 /β2 integrin activation contributes to JAK2-V617F–driven thrombosis [PDF]

, 2018
Barbui, De Stefano, Sands, Stephen T. Oh, Wolach   +4 more
core   +2 more sources

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson, King Long Hannah Lee, Megan Dietz, Sarah Guess, Laura White, Mara S. Varvil   +5 more
wiley   +1 more source

Polycythemia Vera and Essential Thrombocythemia: A Nationwide Population‐Based Study on Treatment Patterns, Vascular Complications and Survival

European Journal of Haematology, Volume 116, Issue 5, Page 545-557, May 2026.
ABSTRACT Background Polycythemia vera (PV) and essential thrombocythemia (ET) are associated with a well‐recognized increased risk of thrombotic events, bleeding, and all‐cause mortality, but the frequency of these outcomes during treatment has rarely been assessed in large cohorts.
Anneli Enblom Larsson, Henrik Renlund, Björn Andréasson, Henrik Holmberg, Maria Liljeholm, Anders Själander   +5 more
wiley   +1 more source