Results 111 to 120 of about 115,857 (253)

Modernising diagnosis and treatment of Chronic Myeloid Leukaemia for improved patient outcomes in a resource-limited setting: Experiences from Ghana’s premier teaching hospital

open access: yesJournal of Interventional Epidemiology and Public Health
Introduction: Until 2013, diagnosis of Chronic Myeloid Leukaemia (CML) at Korle-Bu Teaching Hospital (KBTH) in Ghana was based on white blood cell morphology ascertained from peripheral blood and bone marrow aspirate.
Amma Anima Benneh-Akwasi Kuma   +1 more
doaj   +1 more source

Estimated pulse wave velocity as a marker of major adverse cardiovascular events in essential thrombocythaemia and polycythaemia vera

open access: yesBritish Journal of Haematology, EarlyView.
In patients with essential thrombocythaemia or polycythaemia vera, higher estimated pulse wave velocity (ePWV) was independently associated with major adverse cardiovascular events, while its relationship with overall survival was largely age‐driven.
Alessandro Costa   +6 more
wiley   +1 more source

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto   +12 more
wiley   +1 more source

Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Introduction Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation. Methods We conducted an observational before‐and‐after study including the first non‐tunnelled CVC insertion ...
Mathias Lazarevic Lindblad   +8 more
wiley   +1 more source

P198 | BONE MARROW FIBROSIS IN POLYCYTHEMIA VERA AND ESSENTIAL THROMBOCYTHEMIA: CLINICAL, MOLECULAR AND PROGNOSTIC IMPLICATIONS

open access: yesHaematologica
Background Mild BM fibrosis (MF-1) can be identified in up to 20% of patients (pts) with polycythemia vera (PV) and essential thrombocytemia (ET), and may play a role –albeit still poorly defined–in pathophysiology, clinical presentation ad long-term ...
G. Coltro   +6 more
doaj  

DNA Methylation in Ph-Negative Myeloproliferative Neoplasms: Prognostic Role and Therapeutic Implications

open access: yesCurrent Issues in Molecular Biology
Myeloproliferative neoplasms are clonal hematological neoplasms characterized by excessive proliferation of cells of erythroid, granulocytic, and megakaryocytic lineage.
Paola Barone   +4 more
doaj   +1 more source

Myeloproliferative Neoplasms: Challenging Dogma

open access: yes
Myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis, and primary myelofibrosis are a unique group of clonal hematopoietic stem cell neoplasms that share somatic, gain-in-function driver mutations in JAK2, CALR, and MPL.
Jerry L. Spivak
core   +1 more source

Molecular basis of myelodysplastic/myeloproliferative neoplasms

open access: yes, 2009
The World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues1 includes within myeloid neoplasms the category "Myelodysplastic/myeloproliferative neoplasms".
Reiter, Andreas   +5 more
core   +1 more source

Pregnancy in myeloproliferative neoplasms

open access: yesGaceta Médica de México
Myeloproliferative neoplasms (MPN) are associated with a significant risk of thrombosis and the hypercoagulable environment of pregnancy increases this risk. The most frequent gestational complications consist of spontaneous abortion, thrombosis, bleeding, and hypertensive disease of pregnancy.
Gilberto, Barranco-Lampón   +79 more
openaire   +2 more sources

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo   +8 more
wiley   +1 more source

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