Results 121 to 130 of about 115,857 (253)

JAK2V617F-bearing vascular niche enhances malignant hematopoietic regeneration following radiation injury

Haematologica, 2018
Myeloproliferative neoplasms are clonal stem cell disorders characterized by hematopoietic stem/progenitor cell expansion. The acquired kinase mutation JAK2V617F plays a central role in these disorders.
Chi Hua Sarah Lin, Yu Zhang, Kenneth Kaushansky, Huichun Zhan   +3 more
doaj   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Determinants of clinical phenotype in myeloproliferative neoplasms [PDF]

, 2019
Background: Myeloproliferative neoplasms, (MPNs) such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates.

core   +2 more sources

Cutaneous involvement by myeloid leukaemias: challenging cases with important implications

Histopathology, EarlyView.
Myeloid leukaemias and precursors involving the skin are often challenging to diagnose with varied and overlapping clinical and histopathologic features. Nonetheless, they are critical for pathologists to recognize and accurately classify. This review discusses the clinical, histopathological and genetic features of myelodysplasia cutis (A) and ...
Alexandra C. Hristov
wiley   +1 more source

Autoimmunity and the risk of myeloproliferative neoplasms

, 2010
The causes of myeloproliferative neoplasm (MPN) are unknown. We conducted a large population-based study including 11,039 myeloproliferative neoplasm patients and 43,550 matched controls with the aim of assessing the associations between a personal ...
Björkholm, Magnus, Samuelsson, Jan, Landgren, Ola, Goldin, Lynn R., Kristinsson, Sigurdur Y., Landgren, Carl   +5 more
core   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

C030 | GENOTYPE-PHENOTYPE CORRELATES AND OUTCOMES OF EXTRAMEDULLARY ACUTE MYELOID LEUKEMIA

Haematologica
Background: Genomic abnormalities associated with extramedullary (EM) acute myeloid leukemia (eAML) and their impact on clinical outcomes are not well understood since previous studies were limited to small case series with controversial results.
G.G. Loscocco, F. Mannelli, M. Piccini, B. Scappini, F. Crupi, G. Ciolli, L. Fasano, G. Rotunno, F. Pancani, C. Maccari, L. Signori, P. Guglielmelli, A.M. Vannucchi   +12 more
doaj  

Mutational status of myeloproliferative neoplasms.

, 2010
Philadelphia negative myeloproliferative neoplasms include essential thrombocythemia, polycythemia vera, and primary myelofibrosis. Altered signaling is a hallmark of myeloproliferative neoplasms, as demonstrated by the presence of activating JAK2 (V617F)
RUMI, ELISA, Rumi E, Elena C, ELENA, CHIARA, PASSAMONTI, FRANCESCO   +4 more
core  

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease

, 2014
Genomic regions of acquired uniparental disomy (UPD) are common in malignancy and frequently harbor mutated oncogenes. Homozygosity for such gain-of-function mutations is thought to modulate tumor phenotype, but direct evidence has been elusive ...
Aziz, Athar, Chen, Edwin, Pask, Dean C., Silber, Yvonne, Silber, Y, Manning, Harriet, Rachel Sneade, Saeb-Parsy, K, Athar Aziz, Nangalia, J., Yvonne Silber, Hamilton, T.L., Anna L. Godfrey, Anthony R. Green, Aziz, A., Fink, J, Chen, E., Zhao, X, Green, AR, Nangalia, Jyoti, Xiaodong Zhao, Hamilton, TL, Pask, D.C., Fink, Juergen, Godfrey, AL, Zhao, X., Silber, Y., Sneade, Rachel, Dean C. Pask, Manning, H, Li, J., Ghevaert, Cedric, Find, J., Sneade, R., Sneade, R, Godfrey, Anna L., Kourosh Saeb-Parsy, Green, Anthony R., Liu, P., Li, J, Harriet Manning, Edwin Chen, Liu, P, Pask, DC, Ghevaert, C., Kent, DG, Juergen Fink, Saeb-Parsy, K., Juan Li, Pentao Liu, Nangalia, J, Chen, E, Green, A.R., Manning, H., Hamilton, Tina L., David G. Kent, Aziz, A, Ghevaert, C, Li, Juan, Saeb-Parsy, Kourosh, Kent, D.G., Kent, David G., Tina L. Hamilton, Godfrey, A.L., Zhao, Xiaodong, Cedric Ghevaert, Liu, Pentao, Jyoti Nangalia   +67 more
core   +1 more source

Myelodysplasia‐Related Gene Mutation Burden Is Associated With Complete Remission After Induction Therapy in Acute Myeloid Leukemia, Not Otherwise Specified: Reclassification According to the Updated Classifications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Updated classifications incorporating myelodysplasia‐related (MR) gene mutations reclassify many cases previously diagnosed as acute myeloid leukemia, not otherwise specified (AML, NOS). We evaluated the clinical significance of MR gene mutation burden, defined by mutation number and variant allele frequency (VAF), in AML, NOS ...
Taegeun Lee, Daehyun Chu, Miyoung Kim, Young‐Uk Cho, Sang‐Hyun Hwang, Je‐Hwan Lee, Yunsuk Choi, Eun‐Ji Choi, Ho Joon Im, Hyery Kim, Seongsoo Jang   +10 more
wiley   +1 more source