Results 141 to 150 of about 115,857 (253)

Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower‐risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo‐controlled trial

Cancer, Volume 132, Issue 19, 1 October 2026.
Abstract Background Vitamin C (VitC) is a cofactor for TET enzymes involved in DNA demethylation and epigenetic regulation. Mutations in TET2 are common drivers of leukemia. Preclinical studies suggest that VitC may delay leukemia progression. This study aimed to evaluate the biological activity, safety, and clinical impact of oral VitC in patients ...
Stine Ulrik Mikkelsen, Ali Al‐Mousawi, Amalie Bach Puglisi, Anders Pommer Vallentin, Astrid Østergaard Mortensen, Zachary Madaj, Toshinori Hinoue, Heidi Naomi Ottesen, Jakob Schmidt Jespersen, Linn Gillberg, Morten Tulstrup, Niels Richard Hansen, Jakob Werner Hansen, Mette Klarskov Andersen, Stacey Lyn Thomas, Christine Isaguirre, Ryan Sheldon, Marie Adams, Ryan Burgos, Stephen Baylin, Bo Kok Mortensen, Casey Lee O’Connell, Marianne Tang Severinsen, Peter William Laird, Jens Lykkesfeldt, Peter Jones, Kirsten Grønbæk   +26 more
wiley   +1 more source

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Qi Tian, Yanji Tong, Fang Yu, Xiaoming Hu   +3 more
wiley   +1 more source

The molecular-genetic system for diagnostics myeloproliferative neoplasms

, 2014
Aims. The myeloproliferative neoplasms (MPNs) are a group of diseases characterized by the rapid growth of abnormal uncontrolled proliferation myeloid cells.
Завелевич, М.П., Дибков, М.В., Малюта, С.С., Малюта, О.В., Телегеєв, Г.Д., Поліщук, Л.О., Глузман, Д.Ф.   +6 more
core   +2 more sources

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Long‐term mutational analysis, clonal metrics, and dynamics in patients with chronic idiopathic neutropenia

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract Characterization of the presence and evolution of clonal hematopoiesis (CH) in patients with unexplained cytopenias is fundamental to risk‐stratifying patients and optimizing clinical surveillance for malignant progression. We investigated the mutational spectrum and clonal metrics in a cohort of 256 patients with chronic idiopathic ...
Grigorios Tsaknakis, Irene Mavroudi, Marco Roncador, Anna Maria Perantonaki, Erasmia Boutakoglou, Stavros Papadakis, Anna Gallì, Stamatia Laidou, Charalampos Pontikoglou, Anastasia Chatzidimitriou, Luca Malcovati, Helen A. Papadaki   +11 more
wiley   +1 more source

The German ONKOPEDIA Guideline for Myelofibrosis in 2025—Recommendations of an MPN Expert Panel of the German Society for Hematology and Oncology (DGHO)

International Journal of Cancer, Volume 159, Issue 7, Page 1633-1641, 1 October 2026.
ABSTRACT The recently published ONKOPEDIA guideline on myelofibrosis, issued under the auspices of the German Society of Hematology and Oncology (DGHO), provides an updated, evidence‐based framework for the diagnosis and management of this rare, chronic myeloproliferative neoplasm.
Martin Griesshammer, Haifa Kathrin Al‐Ali, Gabriela M. Baerlocher, Konstanze Döhner, Steffen Koschmieder, Nicolaus Kröger, Petro E. Petrides, Dominik Wolf, Florian H. Heidel   +8 more
wiley   +1 more source

Молекулярно-генетична система діагностики хронічних мієлопроліферативних новоутворень

Фактори експериментальної еволюції організмів, 2014
Aims. The myeloproliferative neoplasms (MPNs) are a group of diseases characterized by the rapid growth of abnormal uncontrolled proliferation myeloid cells.
M. В. Дибков, М. П. Завелевич, Д. Ф. Глузман, Л. О. Поліщук, О. В. Малюта, С. С. Малюта, Г. Д. Телегеєв   +6 more
doaj  

Exposure–Response Analyses of Ropeginterferon Alfa‐2b in Essential Thrombocythemia

The Journal of Clinical Pharmacology, Volume 66, Issue 10, October 2026.
Abstract Ropeginterferon alfa‐2b is a new‐generation interferon therapy for the treatment of myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET). This investigation was designed to characterize its population pharmacokinetics–pharmacodynamics (PopPK‐PD) and delineate exposure–response (E‐R) relationships in ET. A population PK
Albert Qin, Lucia Masarova, Haoqi Chen, Zhijian Xiao, Jie Jin, Harinder Gill, Brandi N Reeves, Firas El Chaer, Keita Kirito, Norio Komatsu, Ghaith Abu‐Zeinah, Kazuya Shimoda, Oleh Zagrijtschuk, Toshiaki Sato, Daoxiang Wu, Lei Wu, Xia Su, Yucheng Gao, Jie Cui, Lei Zhang, Ruben A Mesa   +20 more
wiley   +1 more source

A Retrospective Review of 1821 Cases of Eosinophilia in a Single‐Center Study in Eastern China

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Objective: Our study aims to explore the types of diseases that may cause eosinophilia and the changes in the disease spectrum of different degrees of eosinophilia. Methods We retrospectively analyzed patients who were admitted to the First Affiliated Hospital of Soochow University from July 1, 2023 to June 30, 2024, and had at least twice ...
Yanan Ma, Linlin Wang, Yuexin Cheng, Xiaofei Yang, Suning Chen   +4 more
wiley   +1 more source

Pediatric Essential Thrombocythemia With a Novel CALR Mutation: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Pediatric essential thrombocythemia (ET) is extremely rare and frequently lacks identifiable driver mutations. We report a case of a 5‐year‐old male with ET harboring a novel CALR exon 9 frameshift mutation complicated by acquired von Willebrand syndrome.
Kana Tsuji, Suguru Uemura, Tomoko Fujikawa, Nobuyuki Yamamoto, Aiko Kozaki, Atsuro Saito, Toshiaki Ishida, Takeshi Mori, Makiko Yoshida, Takahiro Okutani, Daiichiro Hasegawa   +10 more
wiley   +1 more source