Results 31 to 40 of about 27,570 (221)

Regulatory Effects of Myo-Inositol on Carbohydrate Metabolism and Low-Salinity Adaptation in Pacific White Shrimp (Penaeus vannamei)

Aquaculture Nutrition
This study investigated how dietary myo-inositol affects osmoregulation, carbohydrate and lipid metabolism, immunity, and antioxidant properties in Penaeus vannamei under long-term low-salinity conditions.
Shengwei Lin, Fenglu Han, Zhao Li, Tong Chang, Zelong Zhang, Xianming Xiao, Yiting Wu, Chang Xu, Erchao Li   +8 more
doaj   +1 more source

Functional Characterization of Pneumocystis carinii Inositol Transporter 1

mBio, 2016
Fungi in the genus Pneumocystis live in the lungs of mammals, where they can cause a fatal pneumonia (PCP [Pneumocystis pneumonia]) in hosts with compromised immune systems.
Melanie T. Cushion, Margaret S. Collins, Thomas Sesterhenn, Aleksey Porollo, Anish Kizhakkekkara Vadukoot, Edward J. Merino   +5 more
doaj   +1 more source

Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women [PDF]

Journal of Ovarian Research, 2018
Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also considering its anti-inflammatory effect.PCOS patients, according to the Rotterdam ESHRE-ASRM criteria, with anovulation and infertility > 1 year ...
Mario Montanino Oliva, Giovanna Buonomo, Marco Calcagno, Vittorio Unfer   +3 more
openaire   +3 more sources

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research projectResearch in context

EBioMedicine
Summary: Background: The metabolic environment plays a crucial role in the development of heart failure (HF). Our prior research demonstrated that myo-inositol, a metabolite transported by the sodium-myo-inositol co-transporter 1 (SMIT-1), can induce ...
Anne-Catherine Pouleur, Nassiba Menghoum, Julien Cumps, Alice Marino, Maria Badii, Sibille Lejeune, Julie Thompson Legault, Gabrielle Boucher, Damien Gruson, Clotilde Roy, Sylvain Battault, Louiza Mahrouche, Valérie Pedneault-Gagnon, Daniel Charpentier, Alexandra Furtos, Julie Hussin, David Rhainds, Jean-Claude Tardif, Luc Bertrand, Christine Des Rosiers, Sandrine Horman, Christophe Beauloye   +21 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Combined Application of Myo-Inositol and Corn Steep Liquor from Agricultural Waste Alleviate Salt Stress in Brassica rapa

Plants, 2023
Salinity poses a significant threat to plant growth through induction of osmotic and ionic stress and disruption of nutrient absorption. Biostimulants derived from agricultural waste offer a sustainable solution to alleviate salt-induced damage to plants
Xinjun Zhang, Xian Wang, Wenna Zhang, Qing Chen   +3 more
doaj   +1 more source

In vivo mapping of brain myo-inositol [PDF]

NeuroImage, 2011
Myo-Inositol (MI) is one of the most abundant metabolites in the human brain located mainly in glial cells and functions as an osmolyte. The concentration of MI is altered in many brain disorders including Alzheimer's disease and brain tumors. Currently available magnetic resonance spectroscopy (MRS) methods for measuring MI are limited to low spatial ...
Mohammad Haris, Kejia Cai, Anup Singh, Hari Hariharan, Ravinder Reddy   +4 more
openaire   +2 more sources

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women:

Journal of the ASEAN Federation of Endocrine Societies, 2023
Background. Myo-inositol has emerged as one of the preventive therapies for the development of gestational diabetes mellitus in at-risk populations.
Patricia Ann Factor, Hannah Corpuz
doaj   +1 more source