Results 41 to 50 of about 61,720 (280)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Regulatory Effects of Myo-Inositol on Carbohydrate Metabolism and Low-Salinity Adaptation in Pacific White Shrimp (Penaeus vannamei)

Aquaculture Nutrition
This study investigated how dietary myo-inositol affects osmoregulation, carbohydrate and lipid metabolism, immunity, and antioxidant properties in Penaeus vannamei under long-term low-salinity conditions.
Shengwei Lin, Fenglu Han, Zhao Li, Tong Chang, Zelong Zhang, Xianming Xiao, Yiting Wu, Chang Xu, Erchao Li   +8 more
doaj   +1 more source

Functional Characterization of Pneumocystis carinii Inositol Transporter 1

mBio, 2016
Fungi in the genus Pneumocystis live in the lungs of mammals, where they can cause a fatal pneumonia (PCP [Pneumocystis pneumonia]) in hosts with compromised immune systems.
Melanie T. Cushion, Margaret S. Collins, Thomas Sesterhenn, Aleksey Porollo, Anish Kizhakkekkara Vadukoot, Edward J. Merino   +5 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research projectResearch in context

EBioMedicine
Summary: Background: The metabolic environment plays a crucial role in the development of heart failure (HF). Our prior research demonstrated that myo-inositol, a metabolite transported by the sodium-myo-inositol co-transporter 1 (SMIT-1), can induce ...
Anne-Catherine Pouleur, Nassiba Menghoum, Julien Cumps, Alice Marino, Maria Badii, Sibille Lejeune, Julie Thompson Legault, Gabrielle Boucher, Damien Gruson, Clotilde Roy, Sylvain Battault, Louiza Mahrouche, Valérie Pedneault-Gagnon, Daniel Charpentier, Alexandra Furtos, Julie Hussin, David Rhainds, Jean-Claude Tardif, Luc Bertrand, Christine Des Rosiers, Sandrine Horman, Christophe Beauloye   +21 more
doaj   +1 more source

The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women:

Journal of the ASEAN Federation of Endocrine Societies, 2023
Background. Myo-inositol has emerged as one of the preventive therapies for the development of gestational diabetes mellitus in at-risk populations.
Patricia Ann Factor, Hannah Corpuz
doaj   +1 more source

Enzymatic fluorometric assay for myo-inositol trisphosphate [PDF]

, 1987
The determination of myo-inositol trisphosphate by an enzymatic fluorometric assay is presented. The method involves the acid extraction of water-soluble inositol polyphosphates followed by separation by anion-exchange chromatography.
Lowry, Oliver H., Morrison, Aubrey R., Shayman, James A.   +2 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia. [PDF]

, 2021
An enhanced requirement for nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy in acute myeloid leukemia (AML), which led to the identification of the myo-inositol transporter SLC5A3 as a dependency
Wei, Yiliang, Costa, Ana S. H., Polyanskaya, Sofya A, Iyer, Shruti, Chang, Kenneth, Skopelitis, Damianos S., McCombie, W. Richard, Huang, Yu-Han, Demerdash, Osama E., Iyer, Shruti V, Vakoc, Christopher R., Demerdash, Osama E, Adelman, Emmalee R, Costa, Ana SH, Yang, Zhaolin, Figueroa, Maria E, Adelman, Emmalee R., Kramer, Melissa, Skopelitis, Damianos S, Hodges, Emily, Vakoc, Christopher R, Polyanskaya, Sofya A., Klingbeil, Olaf, McCombie, W Richard, Goodwin, Sara, Figueroa, Maria E.   +25 more
core   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source