Results 1 to 10 of about 1,509 (158)
D-Chiro-Inositol in Endometrial Hyperplasia: A Pilot Study. [PDF]
Int J Mol Sci, 2023 Endometrial hyperplasia is a threatening pathology driven by unopposed estrogen stimulus. Moreover, insulin may act on the endometrium, prompting further growth. We aimed at assessing whether D-chiro-Inositol, an insulin sensitizer with estrogen-lowering properties, might improve the condition of patients with simple endometrial hyperplasia without ...
Porcaro G +4 more
europepmc +3 more sources
The effect of D-chiro-inositol on renal protection in diabetic mice. [PDF]
Aging (Albany NY), 2022 D-Chiro-inositol (DCI) exerts a hypoglycaemic effect, participates in lipid metabolism and reduces kidney damage. In this study, we preliminarily explored the protective effect of DCI on renal injury in diabetic mice. Male db/db mice were used in this study. After treatment with DCI (35 and 70 mg/kg/d) for 6 consecutive weeks, random blood glucose (RBG)
Fan C +6 more
europepmc +3 more sources
Myo-Inositol and D-Chiro-Inositol as Modulators of Ovary Steroidogenesis: A Narrative Review. [PDF]
Nutrients, 2023 Myo-inositol is a natural polyol, the most abundant among the nine possible structural isomers available in living organisms. Inositol confers some distinctive traits that allow for a striking distinction between prokaryotes and eukaryotes, the basic clusters into which organisms are partitioned.
Bizzarri M +4 more
europepmc +3 more sources
CellsAndrogen excess is a key feature of several clinical phenotypes of polycystic ovary syndrome (PCOS). However, the presence of FSH receptor (FSHR) and aromatase (CYP19A1) activity responses to physiological endocrine stimuli play a critical role in the ...
Valeria Fedeli +9 more
doaj +1 more source
Therapeutic potential of inositol to PCOS: An overview of administration, efficacy, and potential applications [PDF]
Romanian Medical JournalInositol, a group of naturally occurring sugar alcohols, has gained attention for the diverse physiological roles and therapeutic potential. This comprehensive overview examines the administration, efficacy, and potential applications of inositol in ...
Astrit M. Gashi
doaj +1 more source
Pakistan Journal of Medicine and DentistryBackground: Polycystic ovarian syndrome (PCOS) is an endocrinological disease of women of the reproductive age group. The study aimed to compare the efficacy of Myo-inositol and folic acid with and without D-chiro-inositol in the improvement of symptoms
Reja Akram +4 more
doaj +1 more source
New prospects of the integrative therapy for polycystic ovary syndrome in women with the disorders of carbohydrate and lipid metabolism: a comparative study. [PDF]
РМЖ. Мать и дитя, 2020 Yu.E. Dobrokhotova, I.A. Lapina, T.G. Chirvon, V.V. Taranov Pirogov Russian National Research Medical University, Moscow, Russian Federation Background: long-term combined estrogen-progestin oral contraceptive pills (COCPs)
Yu.E. Dobrokhotova +3 more
doaj
The role of inositol in improving fertility in patients with PCOS
Journal of Education, Health and SportIntroduction and purpose Polycystic ovary syndrome is a common reproductive disorder, accompanied primarily by hyperandrogenism and insulin resistance. Myo-inositol (MI) and D-chiro-inositol (DCI), have emerged as potential therapeutic agents due to
Kamila Turek +9 more
doaj +1 more source
Inositols in Insulin Signaling and Glucose Metabolism
International Journal of Endocrinology, 2018 In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Arturo Bevilacqua, Mariano Bizzarri
doaj +1 more source
The Improvement Effect of D-Chiro-Inositol and Ecklonia cava K. in the Rat Model of Polycystic Ovarian Syndrome. [PDF]
Front Pharmacol, 2022 Yang H +7 more
europepmc +1 more source