Results 11 to 20 of about 2,965 (199)

The use of D-chiro-inositol in clinical practice [PDF]

European review for medical and pharmacological sciences, 2021
OBJECTIVE: D-chiro-Inositol has been widely used in clinical practice to induce ovulation in women with polycystic ovary syndrome. Only recent evidence established that this molecule acts through two different mechanisms, with potentially different ...
Aragona C., Bevilacqua A., Bizzarri M., Forte G., Gambioli R., Unfer V.   +5 more
core   +4 more sources

Expression of Concern to: Does ovary need D-chiro-inositol? [PDF]

Journal of Ovarian Research, 2018
Rosalbino Isabella, Emanuela Raffone
doaj   +9 more sources

D-Chiro-Inositol in Endometrial Hyperplasia: A Pilot Study. [PDF]

Int J Mol Sci, 2023
Endometrial hyperplasia is a threatening pathology driven by unopposed estrogen stimulus. Moreover, insulin may act on the endometrium, prompting further growth. We aimed at assessing whether D-chiro-Inositol, an insulin sensitizer with estrogen-lowering properties, might improve the condition of patients with simple endometrial hyperplasia without ...
Porcaro G, Bilotta G, Capoccia E, Bezerra Espinola MS, Aragona C.   +4 more
europepmc   +3 more sources

Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome [PDF]

The EuroBiotech Journal, 2018
It has been known that inositols function as insulin second messengers and mediate different insulin-dependent processes and are a valid natural, non-pharmaceutical alternative to contrast insulin-resistance as well as associated metabolic syndrome in ...
Malvasi Antonio, Tinelli Andrea, Baldini Domenico, Iannitti Rossana G., Fioretti Bernard   +4 more
doaj   +2 more sources

Effect of omega-3 and D-chiro inositol compared to D-chiro inositol alone on hormonal parameters in women with insulin resistant polycystic ovary syndrome [PDF]

International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder marked by high androgen levels, irregular ovulation, and ovarian cysts. Recommended treatments include lifestyle and nutrition changes alongside medication.
Akter, Sohely, Alam, Humaira, Ariful Islam, M., Banu, Jesmine, Hossain, Fawzia, Nessa, Amitun, Sultana, Rebeka, Tarique, Mostafa M. Al   +7 more
core   +3 more sources

The effect of D-chiro-inositol on renal protection in diabetic mice. [PDF]

Aging (Albany NY), 2022
D-Chiro-inositol (DCI) exerts a hypoglycaemic effect, participates in lipid metabolism and reduces kidney damage. In this study, we preliminarily explored the protective effect of DCI on renal injury in diabetic mice. Male db/db mice were used in this study. After treatment with DCI (35 and 70 mg/kg/d) for 6 consecutive weeks, random blood glucose (RBG)
Fan C, Zhang D, Zhang J, Li J, Wang Y, Gao L, Han S.   +6 more
europepmc   +3 more sources

The role of inositol in improving fertility in patients with PCOS [PDF]

Journal of Education, Health and Sport
Introduction and purpose Polycystic ovary syndrome is a common reproductive disorder, accompanied primarily by hyperandrogenism and insulin resistance. Myo-inositol (MI) and D-chiro-inositol (DCI), have emerged as potential therapeutic agents due to
Kamila Turek, Anna Greguła, Karol Stachyrak, Dawid Mika, Aleksandra Kłos, Bartosz Mazur, Maciej Lambach, Mateusz Pawlicki, Aleksandra Mazurek, Wiktoria Wilanowska   +9 more
doaj   +3 more sources

Long-Lasting Therapies with High Doses of D-chiro-inositol: The Downside. [PDF]

J Clin Med, 2023
Background: Recent studies reported possible concerns following long-lasting treatments with high doses of D-chiro-inositol in women. However, to date, no clinical trial has investigated or validated these concerns. We addressed this issue both retrospectively and with a prospective pilot study.
Nordio M, Bezerra Espinola MS, Bilotta G, Capoccia E, Montanino Oliva M.   +4 more
europepmc   +3 more sources

Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials [PDF]

Frontiers in Endocrinology
ObjectivesThis umbrella review aimed to synthesize and appraise the evidence regarding the efficacy of inositol for Polycystic Ovary Syndrome (PCOS) by integrating meta-analyses of randomized controlled trials(RCTs), thereby assessing the robustness of ...
Mengxue Duan, Mengxue Duan, Min Yang, Min Yang, Chang Li, Chang Li, Xiao Wu, Xiao Wu, Xiaoxiao Yin, Xiaoxiao Yin, Hongqiu Zhu, Hongqiu Zhu   +11 more
doaj   +2 more sources

D-Chiro-Inositol and LPS Induce a PCOS-Like Hyperandrogenic Response in Human KGN Granulosa Cells. [PDF]

J Cell Mol Med
ABSTRACT Hyperandrogenism is a key hallmark of polycystic ovary syndrome, a prevalent endocrine disorder affecting women of reproductive age and often leading to infertility. We previously observed that high doses of D‐chiro‐inositol in mice reduce ovarian aromatase expression, contributing to a hyperandrogenic state.
Giuliani C, Casoli G, Di Emidio G, Tatone C, Bevilacqua A.   +4 more
europepmc   +2 more sources