D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes [PDF]
Frontiers in Endocrinology, 2021 D-Chiro-Inositol (D-Chiro-Ins) is a secondary messenger in the insulin signaling pathway. D-Chiro-Ins modulates insulin secretion, the mitochondrial respiratory chain, and glycogen storage.
Maria Magdalena Montt-Guevara +6 more
doaj +2 more sources
New Insights into the Activities of D-Chiro-Inositol: A Narrative Review [PDF]
Biomedicines, 2021 D-chiro-inositol (DCI) is a natural compound detectable in cell membranes, which is highly conserved as a biological signaling molecule. In mammals, its function is primarily characterized in the intracellular transduction cascade of insulin.
Riccardo Gambioli +5 more
doaj +2 more sources
D‐Chiro‐Inositol and LPS Induce a PCOS‐Like Hyperandrogenic Response in Human KGN Granulosa Cells [PDF]
Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.ABSTRACT Hyperandrogenism is a key hallmark of polycystic ovary syndrome, a prevalent endocrine disorder affecting women of reproductive age and often leading to infertility. We previously observed that high doses of D‐chiro‐inositol in mice reduce ovarian aromatase expression, contributing to a hyperandrogenic state.
Cristiano Giuliani +4 more
wiley +2 more sources
The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes [PDF]
International Journal of Endocrinology, 2016 Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes. Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance.
Basilio Pintaudi +2 more
doaj +2 more sources
Does ovary need D-chiro-inositol? [PDF]
Journal of Ovarian Research, 2012 Backgroud Polycystic Ovary Syndrome (PCOS) is a multifactorial pathology that affects 10% of the women in reproductive age being the main cause of infertility due to menstrual dysfunction.
Isabella Rosalbino, Raffone Emanuela
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Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data [PDF]
International Journal of Endocrinology, 2016 Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome.
Mario Mancini +5 more
doaj +2 more sources
NMR Identification and Quantification of Galactinol in Green Coffea arabica: Implications for Traceability and Adulteration [PDF]
Journal of Food Science, Volume 91, Issue 6, June 2026.ABSTRACT Among coffee low‐molecular‐weight carbohydrates, galactinol plays an important role in coffee physiology and quality, having received attention also for its potential use as a marker of geographical origin. Nevertheless, data on the occurrence of this sugar in green coffee beans remain limited.
Elisabetta De Angelis +7 more
wiley +2 more sources
Potential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review [PDF]
CellsBackground: Anxiety is a frequent clinical problem that becomes disabling when excessive or persistent. Cyclitols are naturally occurring polyhydroxy compounds, and inositols are the most abundant cyclitols in eukaryotic cells; several stereoisomers have
Maria Derkaczew +4 more
doaj +2 more sources
Advances in the management of osteopenia: a case series [PDF]
Journal of Medical Case ReportsBackground Osteopenia is a pre-pathological condition characterized by reduced bone mineral density that may lead to increased fracture risk and to the onset of osteoporosis. Standard treatments for managing osteopenia include supplementation of calcium,
Maurizio Nordio, Roberto Baldelli
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Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials [PDF]
Frontiers in EndocrinologyObjectivesThis umbrella review aimed to synthesize and appraise the evidence regarding the efficacy of inositol for Polycystic Ovary Syndrome (PCOS) by integrating meta-analyses of randomized controlled trials(RCTs), thereby assessing the robustness of ...
Mengxue Duan +11 more
doaj +2 more sources