Stereoselective Voltammetric Biosensor for Myo-Inositol and D-Chiro-Inositol Recognition [PDF]
Sensors, 2023 This paper describes the development of a simple voltammetric biosensor for the stereoselective discrimination of myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) by means of bovine serum albumin (BSA) adsorption onto a multi-walled carbon ...
Riccarda Antiochia +2 more
exaly +7 more sources
New Insights into the Activities of D-Chiro-Inositol: A Narrative Review [PDF]
Biomedicines, 2021 D-chiro-inositol (DCI) is a natural compound detectable in cell membranes, which is highly conserved as a biological signaling molecule. In mammals, its function is primarily characterized in the intracellular transduction cascade of insulin.
Maurizio Nordio +2 more
exaly +7 more sources
D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes [PDF]
Frontiers in Endocrinology, 2021 D-Chiro-Inositol (D-Chiro-Ins) is a secondary messenger in the insulin signaling pathway. D-Chiro-Ins modulates insulin secretion, the mitochondrial respiratory chain, and glycogen storage.
Maria Magdalena Montt-Guevara +6 more
doaj +6 more sources
Does ovary need D-chiro-inositol? [PDF]
Journal of Ovarian Research, 2012 Backgroud Polycystic Ovary Syndrome (PCOS) is a multifactorial pathology that affects 10% of the women in reproductive age being the main cause of infertility due to menstrual dysfunction.
Isabella Rosalbino, Raffone Emanuela
doaj +6 more sources
Long-Lasting Therapies with High Doses of D-chiro-inositol: The Downside [PDF]
Journal of Clinical Medicine, 2023 Background: Recent studies reported possible concerns following long-lasting treatments with high doses of D-chiro-inositol in women. However, to date, no clinical trial has investigated or validated these concerns. We addressed this issue both retrospectively and with a prospective pilot study.
Maurizio Nordio +2 more
exaly +4 more sources
D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers: a pilot study [PDF]
Basic and Clinical Andrology, 2021 Résumé Contexte L’insuffisance en androgènes affecte les hommes à l’âge adulte, causant plusieurs effets nocifs aux niveaux reproductif et comportemental. Puisque l’aromatase est.
Giovanni Monastra +5 more
doaj +2 more sources
D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence [PDF]
Journal of Clinical Medicine, 2020 The use of inositols in endocrinological clinical practice is increasingly widespread. Most of the existing evidence concerns myoinositol (MYO), the most abundant form in nature, especially in women with polycystic ovarian syndrome. We have previously shown that MYO increases sperm motility in patients with asthenozoospermia by the increase of sperm ...
Aldo E Calogero +2 more
exaly +5 more sources
D-Chiro-Inositol and LPS Induce a PCOS-Like Hyperandrogenic Response in Human KGN Granulosa Cells. [PDF]
J Cell Mol MedABSTRACT Hyperandrogenism is a key hallmark of polycystic ovary syndrome, a prevalent endocrine disorder affecting women of reproductive age and often leading to infertility. We previously observed that high doses of D‐chiro‐inositol in mice reduce ovarian aromatase expression, contributing to a hyperandrogenic state.
Giuliani C +4 more
europepmc +2 more sources
The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes [PDF]
International Journal of Endocrinology, 2016 Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes. Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance.
Basilio Pintaudi +2 more
doaj +2 more sources
Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data [PDF]
International Journal of Endocrinology, 2016 Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome.
Mario Mancini +5 more
doaj +2 more sources