Results 51 to 60 of about 60,147 (299)

Regulatory Effects of Myo-Inositol on Carbohydrate Metabolism and Low-Salinity Adaptation in Pacific White Shrimp (Penaeus vannamei)

Aquaculture Nutrition
This study investigated how dietary myo-inositol affects osmoregulation, carbohydrate and lipid metabolism, immunity, and antioxidant properties in Penaeus vannamei under long-term low-salinity conditions.
Shengwei Lin, Fenglu Han, Zhao Li, Tong Chang, Zelong Zhang, Xianming Xiao, Yiting Wu, Chang Xu, Erchao Li   +8 more
doaj   +1 more source

Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research projectResearch in context

EBioMedicine
Summary: Background: The metabolic environment plays a crucial role in the development of heart failure (HF). Our prior research demonstrated that myo-inositol, a metabolite transported by the sodium-myo-inositol co-transporter 1 (SMIT-1), can induce ...
Anne-Catherine Pouleur, Nassiba Menghoum, Julien Cumps, Alice Marino, Maria Badii, Sibille Lejeune, Julie Thompson Legault, Gabrielle Boucher, Damien Gruson, Clotilde Roy, Sylvain Battault, Louiza Mahrouche, Valérie Pedneault-Gagnon, Daniel Charpentier, Alexandra Furtos, Julie Hussin, David Rhainds, Jean-Claude Tardif, Luc Bertrand, Christine Des Rosiers, Sandrine Horman, Christophe Beauloye   +21 more
doaj   +1 more source

Topological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]

, 2016
Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.
Argoud, K, Ayala, R, Calderari, S, Cazier, JB, Collins, S, Domange, C, Dumas, ME, Gauguier, D, Gu, Q, Holmes, E, Hue, C, Lindon, JC, Mitchell, S, Navratil, V, Nicholson, JK, Otto, GW, Rodriguez Martinez, A, Suárez-Zamorano, N, Wallis, R, Wang, Y, Wilder, S   +20 more
core   +6 more sources

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Combined Application of Myo-Inositol and Corn Steep Liquor from Agricultural Waste Alleviate Salt Stress in Brassica rapa

Plants, 2023
Salinity poses a significant threat to plant growth through induction of osmotic and ionic stress and disruption of nutrient absorption. Biostimulants derived from agricultural waste offer a sustainable solution to alleviate salt-induced damage to plants
Xinjun Zhang, Xian Wang, Wenna Zhang, Qing Chen   +3 more
doaj   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women:

Journal of the ASEAN Federation of Endocrine Societies, 2023
Background. Myo-inositol has emerged as one of the preventive therapies for the development of gestational diabetes mellitus in at-risk populations.
Patricia Ann Factor, Hannah Corpuz
doaj   +1 more source

Characterization of myo-inositol oxygenase from rice (OsMIOX): influence of salinity stress in different indica rice cultivars [PDF]

, 2023
Sanghamitra Adak, Tanushree Agarwal, Priyanka Das, Sudipta Ray, Arun Lahiri Majumder   +4 more
openalex   +1 more source

Metabolic engineering of micronutrients in crop plants [PDF]

, 2016
Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products
Blancquaert, Dieter, De Steur, Hans, Gellynck, Xavier, Van Der Straeten, Dominique   +3 more
core   +2 more sources

Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Advanced Science, EarlyView.
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen   +10 more
wiley   +1 more source