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Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organization

Developmental Biology, 2008
Members of the CDM (CED-5, Dock180, Myoblast city) superfamily of guanine nucleotide exchange factors function in diverse processes that include cell migration and myoblast fusion.
Erika R Geisbrecht, Selene K Swanson, Laurence Florens   +2 more
exaly   +2 more sources

RhoE controls myoblast alignment prior fusion through RhoA and ROCK

Cell Death and Differentiation, 2008
International audienceDifferentiation of skeletal myoblasts into multinucleated myotubes is a multi-step process orchestrated by several signaling pathways. The Rho small G protein family plays critical roles both during myogenesis induction and myoblast
Anne Blangy, Cecile Gauthier-Rouvière
exaly   +2 more sources

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Myoblast transplantation

Neuromuscular Disorders, 2002
Myoblast transplantation was the first quasi-gene therapy to be suggested for Duchenne muscular dystrophy. Animal experiments established the principles that the missing gene could be targeted to muscle by grafting of genetically normal myoblasts that were able to repair the disease-damaged muscle fibres.
Daniel Skuk, Jacques P. Tremblay
openaire   +3 more sources

Myoblasts, Satellite Cells, and Myoblast Transfer

1990
The prospects for introducing “foreign” nuclei through the cell fusion process have been considered since it first became clear that skeletal muscle fibers form by fusion of many mononucleated myoblasts rather than the proliferation of skeletal muscle nuclei within fibers (Stockdale and Holtzer, 1961).
F E, Stockdale, E J, Hager, S E, Fernyak, J X, DiMario   +3 more
openaire   +2 more sources

Rapid death of injected myoblasts in myoblast transfer therapy

Muscle & Nerve, 1996
Myoblast transplantation has been proposed as a potential therapy for Duchenne muscular dystrophy (DMD). A Y-chromosome-specific probe was used to track the fate of donor male myoblasts injected into dystrophic muscles of female mdx mice (which are an animal model for DMD).
Y, Fan, M, Maley, M, Beilharz, M, Grounds   +3 more
openaire   +2 more sources

Myoblast differentiation in vitro: Morphological differentiation of mononucleated myoblasts

Developmental Biology, 1976
Abstract Phospholipase C from Clostridium perfringens has been shown previously to inhibit the fusion of cultured chick myoblasts without affecting recognition or cell cycle parameters. In this paper we report that the mononucleated myoblasts, in phospholipase C, synthesize thick and thin filaments and organize them into myofibrils, and that T ...
J A, Trotter, M, Nameroff
openaire   +2 more sources