Results 81 to 90 of about 1,794 (168)

Investigating Hybrid PLGA-Lipid Nanoparticles as an Innovative Delivery Tool for Palmitoylethanolamide to Muscle Cells

Pharmaceutics
Background/Objectives: Palmitoylethanolamide (PEA) is an endogenous lipid mediator with endocannabinoid-like activity. Despite its therapeutic potential in muscle-related inflammatory disorders, including sarcopenia, its clinical use is limited by poor ...
Eleonora Maretti, Susanna Molinari, Sonia Partel, Beatrice Recchia, Cecilia Rustichelli, Eliana Leo   +5 more
doaj   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, EarlyView.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

A Platform for the Actuation of Magnetically Labeled Skeletal Muscle Cells Using Dynamic Magnetic Stimulation

Small, EarlyView.
A magnetic stimulation platform for the remote stimulation of cells is presented, consisting of a magnetic stimulator and magnetic microspheres. Skeletal muscle cells are labeled with magnetic microspheres, which act as local magnetic actuators on the cells upon application of the magnetic field.
Tayná C. Rodrigues, Anna‐Lena Bauknecht, Anna Gioran, Sabine Rosenfeldt, Daniel Dickes, Johann Schorzmann, Frank Döpper, Elisabetta A. Cavalcanti‐Adam, Michael Maier, Reinhard Richter, Marissa K. Caldow, Gordon S. Lynch, Daniel E. Heath, Andrea J. O'Connor, Sahar Salehi   +14 more
wiley   +1 more source

Acoustic Tweezers‐Assisted Biomaterial Molding in Petri Dishes (TAMP) for Engineering Glioma Tissues With Controlled Cellular and Extracellular Matrix Architectures

Small, EarlyView.
This study introduces an acoustics‐assisted tissue engineering approach, termed “Acoustic Tweezers‐Assisted Biomaterial Molding in Petri Dishes (TAMP),” which enables the fabrication of tissues with customizable extracellular matrix (ECM) geometries and various acoustically constructed internal cellular architectures, including parallel elongated ...
Yingshan Du, Jiali Li, Hui Liu, Julio P. Arroyo, Luyu Bo, Bowen Cai, Teng Li, Zhide Wang, Chongpeng Qiu, Rafael Davalos, Joseph Rich, Zhenhua Tian   +11 more
wiley   +1 more source

Triplet Energy Transfer Strategy for Visible Light Activation of Bio‐Based Oxime Esters in Photopolymerization and 3D Printing

Small, EarlyView.
Bio‐based oxime esters are converted into efficient metal‐free photoinitiators for 405 nm LEDs and sunlight by Dexter‑type triplet energy transfer from ITX, enabling fast and deep visible light curing, high‐resolution 3D printing and improved cytocompatibility.
Kaidan Yang, Céline Dietlin, Coralie Ohl, Margot Manivel, Fabrice Morlet‐Savary, Michael Schmitt, Gérard Audran, Jean‐Patrick Joly, Jing Zhang, Pu Xiao, Jacques Lalevée   +10 more
wiley   +1 more source

MXene Bioinks for 3D Bioprinting: Design and Translation

Small, EarlyView.
This study establishes a comprehensive framework for MXene‐based bioinks in 3D bioprinting, highlighting the interplay between rheological engineering and electroactive hydrogels. By optimizing electrical percolation and mediated signaling, these formulations drive tissue‐specific biological outcomes and accelerated regeneration.
Begüm Sarac, Seydanur Yücer, Fatih Ciftci   +2 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source