Identification of transition factors in myotube formation from proteome and transcriptome analyses
Journal of Integrative Agriculture, 2023 Muscle fibers are the main component of skeletal muscle and undergo maturation through the formation of myotubes. During early development, a population of skeletal muscle satellite cells (SSCs) proliferate into myoblasts.
Hong-Guo Cao
exaly +4 more sources
Effects of Nintedanib on Orofacial Fibroblasts and Myoblasts [PDF]
BiomoleculesFollowing surgical interventions or acquired trauma, fibrosis often inhibits muscle and skin regeneration. Nintedanib, an antifibrotic drug for lung fibrosis, may help prevent orofacial fibrosis. This study evaluates Nintedanib’s potential for inhibiting
Zhihao Wang +3 more
doaj +2 more sources
The uncoordinated‐5 homologue A is a key receptor in netrin‐ligand‐mediated fast‐twitch myotube formation in male mice [PDF]
Physiological ReportsMyoblasts autonomously govern myofiber‐type specification of newly formed myotubes through autocrine–paracrine‐dependent manners mediated by multipotent modulators.
Takahiro Maeno +15 more
doaj +2 more sources
Impact of C4BPA on Muscle progenitor cell differentiation: insights for Duchenne muscular dystrophy treatment [PDF]
Cell Death and DiseaseFibroadipogenic precursor cells (FAPs) are key contributors to the fibrotic and adipogenic remodeling observed in Duchenne muscular dystrophy (DMD), yet their precise role in muscle degeneration remains unclear.
Esther Fernández-Simón +12 more
doaj +2 more sources
Myotube/Adipocyte Powder-Enriched Alginate–Zein Hydrogels Support Myotube Alignment for 3D Myoblast Culture [PDF]
FoodsRecent advances in cultured-meat research emphasize the development of edible scaffolds that promote myogenic differentiation. Nonetheless, many materials provide only structural support and do not replicate native muscle or serve as alternatives to ...
Jihad Kamel +6 more
doaj +2 more sources
Myotube formation on micropatterns guiding by centripetal cellular motility and crowding
Materials Today BioThe physical microenvironment, including substrate rigidity and topology, impacts myoblast differentiation and myotube maturation. However, the interplay effect and physical mechanism of mechanical stimuli on myotube formation is poorly understood.
Yanning Ma, Jun Qiu, Hao Zhang
exaly +3 more sources
Applied Sciences, 2023 Sarcopenia is an aging-related disease that involves the gradual loss of muscle mass and function. However, no suitable therapeutic drugs are currently available. Accordingly, the purpose of the present study was to evaluate the effectiveness of rosemary
Jun Ho Lee +6 more
doaj +1 more source
Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured Myotubes
Frontiers in Physiology, 2021 Myotubes are mature muscle cells that form the basic structural element of skeletal muscle. When stretching skeletal muscles, myotubes are subjected to passive tension as well.
Dapeng Ren +8 more
doaj +1 more source
Cells, 2021 Duchenne muscular dystrophy (DMD) is a genetic disorder that results from deficiency of the dystrophin protein. In recent years, DMD pathological models have been created using induced pluripotent stem (iPS) cells derived from DMD patients.
Kantaro Yoshioka +10 more
doaj +1 more source
In Vitro Effects of PTH (1-84) on Human Skeletal Muscle-Derived Satellite Cells
Biomedicines, 2023 Parathyroid hormone (PTH) is a hormone secreted by the parathyroid glands. Despite its well-known characterized anabolic and catabolic actions on the skeleton, the in vitro effects of PTH on skeletal muscle cells are limited and generally performed on ...
Cecilia Romagnoli +6 more
doaj +1 more source