Results 11 to 20 of about 18,015 (263)
Protective Effect of Pyropia yezoensis Peptide on Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes [PDF]
Marine Drugs, 2019 Dexamethasone (DEX), a synthetic glucocorticoid, causes skeletal muscle atrophy. This study examined the protective effects of Pyropia yezoensis peptide (PYP15) against DEX-induced myotube atrophy and its association with insulin-like growth factor-I ...
Min-Kyeong Lee +3 more
doaj +4 more sources
A role for phospholipase D3 in myotube formation.
PLoS ONE, 2012 Phospholipase D3 (PLD3) is a non-classical, poorly characterized member of the PLD superfamily of signaling enzymes. PLD3 is a type II glycoprotein associated with the endoplasmic reticulum, is expressed in a wide range of tissues and cells, and ...
Mary Osisami +2 more
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BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function [PDF]
International Journal of Environmental Research and Public Health, 2021 BST204 is a purified ginseng dry extract that has an inhibitory effect on lipopolysaccharide-induced inflammatory responses, but its effect on muscle atrophy is yet to be investigated. In this study, C2C12 myoblasts were induced to differentiate for three days followed by the treatment of dexamethasone (DEX), a corticosteroid drug, with vehicle or ...
Ryuni Kim +8 more
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Small Molecules Driving Myotube Fission [PDF]
Chemistry & Biology, 2005 In this issue of Chemistry & Biology, Duckmanton et al. have rigorously studied myotube fragmentation, or "cellularization," triggered by microtubule-disrupting agents. They convincingly demonstrate that cellularization remains integral to myogenic dedifferentiation, but is insufficient for reentry of the mononucleate progeny into the cell cycle.
Hines, John
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Myotube Guidance: Shaping up the Musculoskeletal System
Journal of Developmental BiologyMyofibers are highly specialized contractile cells of skeletal muscles, and dysregulation of myofiber morphogenesis is emerging as a contributing cause of myopathies and structural birth defects.
Aaron N. Johnson
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Control of myotube orientation using ultrasonication
Scientific ReportsThis study investigated a technique for controlling the orientation of C2C12-derived myotube cells using ultrasonication for future clinical applications of cultured skeletal muscle tissues. An ultrasonicating cell culture dish, comprising a plastic-bottomed culture dish and a circular glass plate (diameter, 35 mm; thickness, 1.1 mm) attached to an ...
Ryohei Hashiguchi +3 more
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Pyropia yezoensis Protein Prevents Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes [PDF]
Marine Drugs, 2018 Glucocorticoids (GCs), which are endocrine hormones released under stress conditions, can cause skeletal muscle atrophy. This study investigated whether Pyropia yezoensis crude protein (PYCP) inhibits synthetic GCs dexamethasone (DEX)-induced myotube ...
Min-Kyeong Lee +3 more
doaj +3 more sources
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation [PDF]
Nature Communications, 2018 Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by ...
Masaki Tsuchiya +20 more
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Culturing C2C12 myotubes on micromolded gelatin hydrogels accelerates myotube maturation [PDF]
Skeletal Muscle, 2019 Skeletal muscle contributes to roughly 40% of lean body mass, and its loss contributes to morbidity and mortality in a variety of pathogenic conditions. Significant insights into muscle function have been made using cultured cells, in particular, the C2C12 myoblast line.
Lance T. Denes +6 more
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Fusion of Normoxic- and Hypoxic-Preconditioned Myoblasts Leads to Increased Hypertrophy
Cells, 2022 Injuries, high altitude, and endurance exercise lead to hypoxic conditions in skeletal muscle and sometimes to hypoxia-induced local tissue damage. Thus, regenerative myoblasts/satellite cells are exposed to different levels and durations of partial ...
Tamara Pircher +5 more
doaj +1 more source