Results 91 to 100 of about 78,749 (287)

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Micro‐Scale Topography Triggers Dynamic 3D Nuclear Deformations

Advanced Science
Navigating complex extracellular environments requires extensive deformation of cells and their nuclei. Most in vitro systems used to study nuclear deformations impose whole‐cell confinement that mimics the physical crowding experienced by cells during ...
Claire Leclech, Giulia Cardillo, Bettina Roellinger, Xingjian Zhang, Joni Frederick, Kamel Mamchaoui, Catherine Coirault, Abdul I. Barakat   +7 more
doaj   +1 more source

Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]

, 1997
The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Adams, Aigner, Arber, Arber, Arber, Ashby, Blank, Buckingham, Chevallier, Chien, Chiquet, Chu, Condon, Connor, deLapeyriére, Duxson, Fontaine, Gatchalian, Grayson, Hauschka, Hilfer, Imaizumi-Scherrer, Jellies, Lance-Jones, Lanser, McMahon, Olson, Ontell, Rechsteiner, Ross, Schaeren-Wiemers, Schroeter, Schroeter, Shaw, Sweeney, Tucker, Witzemann, Zou   +37 more
core   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

The Effect of Microfluidic Geometry on Myoblast Migration

Micromachines, 2019
In vitro systems comprised of wells interconnected by microchannels have emerged as a platform for the study of cell migration or multicellular models.
Rahul Atmaramani, Bryan J. Black, Kevin H. Lam, Vinit M. Sheth, Joseph J. Pancrazio, David W. Schmidtke, Nesreen Zoghoul Alsmadi   +6 more
doaj   +1 more source

Farewell to Professor David Yaffe – A Pillar of the Myogenesis Field

European Journal of Translational Myology, 2020
It is with great sadness that we have learned about the passing of Professor David Yaffe (1929-2020, Israel). Yehi Zichro Baruch - May his memory be a blessing. David was a man of family, science and nature.
Zipora Yablonka-Reuveni, Frank Stockdale, Uri Nudel, David Israeli, Helen M. Blau, Asher Shainberg, Sara Neuman, Gania Kessler-Icekson, Erica Meghid Krull, Bruce Paterson, Ora Saxel Fuchs, David Greenberg, Rachel Sarig, Orna Halevy, Eijiro Ozawa, Don J. Katcoff   +15 more
doaj   +1 more source

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network [PDF]

, 2019
Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their
Alessio, Enrico, Bertoli, Alessandro, Buson, Lisa, Cagnin, Stefano, Chemello, Francesco, Grespi, Francesca, Lanfranchi, Gerolamo, Martini, Paolo, Massimino, Maria L, Millino, Caterina, Pacchioni, Beniamina, Peggion, Caterina, Romualdi, Chiara, Scorrano, Luca   +13 more
core   +1 more source

Biocompatible Magnetopyroelectric Composite Films for Cell Stimulation

Advanced Science, EarlyView.
Magnetopyroelectric films couple Fe3O4 nanoparticles with pyroelectric P(VDF‐TrFE) to turn alternating magnetic fields into controlled heat and pyroelectric currents. This heavy‐metal free platform safely boosts neural progenitor cells differentiation via synergistic thermal and pyroelectrical cues, engages AKT and calcium pathways, and opens practical
Hao Ye, Joaquin Llacer‐Wintle, Semih Sevim, Elric Zhang, Denis von Arx, Lukas Hertle, Martina Accursi, Minsoo Kim, Josep Puigmartí‐Luis, Bradley J. Nelson, Xiang‐Zhong Chen, Salvador Pané   +11 more
wiley   +1 more source

Four and a half LIM protein 1C (FHL1C) [PDF]

, 2011
Four-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy
Binder, Josepha, Desoye, Gernot, Gorischek, Astrid, Hochmeister, Sonja, Malle, Ernst, Miedl, Heidi, Poparic, Ivana, Quasthoff, Stefan, Schoser, Benedikt, Schreibmayer, Wolfgang, Wagner, Klaus, Windpassinger, Christian   +11 more
core   +1 more source