Results 101 to 110 of about 54,075 (312)
The 9th International RASopathies Symposium
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel +41 more
wiley +1 more source
Differentiation and proliferation of respiration-deficient human myoblasts
, 1993 Replication and transcription of mitochondrial DNA were impaired in dividing human myoblasts exposed to ethidium bromide. MtDNA content decreased linearly per cell division and mitochondrial transcript levels declined rapidly, resulting in respiration ...
Zwart, R. +6 more
core +1 more source
Advanced NanoBiomed Research, EarlyView.We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer +5 more
wiley +1 more source
The Effect of Pax3 Over-expression on Myoblast Function
, 2009 The paired-box transcription factor 3 (Pax3), is a powerful myogenic regulatory factor during embryo-myogenesis. The expression of Pax3 is involved in determining somitic cell fate, resulting in the formation of the first differentiated muscle, the ...
Brijs, Erik
core
Untagged β-TM constructs form abnormal aggregates in human myoblasts.
, 2013 Human myoblasts transfected with untagged WT-, E41K-, K49del- and G53ins-β-TM constructs and labeled with phalloidin (green) and β-TM (red) and DAPI (blue) to highlight cell nuclei.
Saba Abdul-Hussein (456874) +3 more
core +1 more source
Myoblasts expressing truncated PTN showed no sign of ER stress.
, 2013 ER stress-induced CHOP expression was detected in LacZ myoblasts treated with 5 µg/ml tunicamycin as a positive control, while no expression was found in untreated T-PTN, PTN, and LacZ myoblasts.
Minako Usui (405184) +17 more
core +1 more source
ANALYSIS OF NUCLEAR MORPHOLOGY OF DESMIN KNOCK-OUT MYOBLASTS [PDF]
, 2020 Desminopathies are degenerative muscle diseases caused by mutations of the desmin gene. Desmin is an intermediate filament protein that is mainly expressed in smooth muscles, skeletal muscles and cardiac muscles cells.
Honscheid, Elena Anna-Maria
core
Animal Research and One Health, EarlyView.This study identified a molecule named lncRSFD, which is highly expressed in sheep adipose tissues. The lncRSFD gene generates two distinct transcript variants via alternative splicing: lncRSFD‐L and lncRSFD‐S. Functionally, lncRSFD alternative splicing (lncRSFD‐L/S) promotes the proliferation, differentiation, and lipid metabolism of adipocytes ...
Jinpeng Wang +9 more
wiley +1 more source
Genomic Structural Variations Provide Insights Into Litter Size and Teat Number Traits in Hu Sheep
Animal Research and One Health, EarlyView.Here, we conducted whole genome sequencing on 300 Hu sheep with an average depth of 16.51X. Two candidate genes associated with litter size and teat number traits were identified, namely MAST2 and AFDN. ABSTRACT Litter size and the teat number are important economic indicators in sheep production.
Xin Xiang +3 more
wiley +1 more source
S100B protein activates quiescent myoblasts and muscle satellite cells.
, 2006 Treatment of high-density myoblast cell lines or primary myoblasts (satellite cells) in differentiation medium (DM) with pM amounts of S100B results in inhibition of differentiation, stimulation of proliferation and inhibition of apoptosis (Mol Cell ...
DONATO, Rosario Francesco +2 more
core