Results 91 to 100 of about 54,075 (312)

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Bidirectional Myoblast-Pericyte Plasticity [PDF]

Developmental Cell, 2013
Microvascular pericytes are able to generate multiple mesenchymal cell types, including skeletal muscle myoblasts. Cappellari et al. (2013) report in this issue of Developmental Cell that myoblasts can return the favor by generating pericytes via the action of Dll4 Notch ligand and PDGF-BB.
openaire   +2 more sources

Primary myoblasts from POUND mice show impaired proliferation and differentiation.

, 2013
A. Primary myoblasts cultures from wild-type and POUND mice show a significant decrease in the proliferation and metabolic activity of myoblasts in POUND mice compared to normal wild-type mice as measured using MTS assay (left panel). B.
Phonepasong Arounleut (445842), Xing-Ming Shi (179793), Maribeth H. Johnson (345072), Carlos M. Isales (154141), Alexis M. Stranahan (129483), Sadanand Fulzele (445845), Mark W. Hamrick (445847), Matthew Bowser (445843), Sunil Upadhyay (445844), William D. Hill (445846)   +9 more
core   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

POLB Regulates Proliferation and Apoptosis of Bovine Primary Myocytes

Animals
DNA polymerase β (DNA polymerase beta (POLB)) belongs to a member of the DNA polymerase X family, mainly involved in various biological metabolic processes, such as eukaryotic DNA replication, DNA damage repair, gene recombination, and cell cycle ...
Geyang Zhang, Jiamei Wang, Yulong Li, Zijing Zhang, Xiangnan Wang, Fuying Chen, Qiaoting Shi, Yongzhen Huang, Eryao Wang, Shijie Lyu   +9 more
doaj   +1 more source

Human myoblasts in in vitro culture.

, 2013
A – flow cytometry analysis of CD56 expression on human myoblasts. Mean percent of cells positive for the CD56 marker: 85.0+/−5.0%. Panel B - in vitro culture of myoblasts and myocytes (Mb24 hrs – proliferating myoblasts; Mc7d- fused myocytes (myotubes).
Maciej Kurpisz (362146), Piotr Pawlak (140082), Tomasz Mietkiewski (453371), Marcin Siatkowski (171726), Tomasz Kolanowski (453368), Agnieszka Malcher (453370), Marta Olszewska (453372), Natalia Rozwadowska (453367), Ewa Wiland (453369)   +8 more
core   +1 more source

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Ion‐Permeable Electrospun Scaffolds Enable Controlled In‐Vitro Electrostimulation Assay of Myoblasts

Advanced Materials Interfaces
In‐vitro models are fundamental for studying muscular cell contractility and for wide‐screening of therapeutic candidates targeting skeletal muscle diseases, owing to their scalability, reproducibility, and circumvention of ethical concerns.
Serafina Pacilio, Francesco Decataldo, Roberta Costa, Tobias Cramer, Beatrice Fraboni, Giovanna Cenacchi, Maria Letizia Focarete   +6 more
doaj   +1 more source

Angiogenic factors expressed in MyoD^−/− myoblasts.

, 2013
(A) Expression of growth factor related genes in wild-type and MyoD−/− myoblasts was confirmed by semi-quantitative RT-PCR. RNA was isolated from wild-type and MyoD−/− myoblasts grown in growth medium (GM), differentiation medium (DM), or under skeletal ...
Amanda J. Christ (314210), Minoru Yoshiyama (314215), Hiroyuki Hirai (159278), Bryan A. Piras (314201), Yoko Asakura (314198), Mayank Verma (314207), Jianyi Zhang (104103), Christopher T. Tastad (314204), Atsushi Asakura (314217), Yasuhiro Nakamura (312045), Takanori Yamazaki (314213)   +10 more
core   +1 more source