Results 81 to 90 of about 79,103 (214)

Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy [PDF]

, 2018
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by ...
Díaz Manera, Jordi, Escudero Cuadrado, Luis María, Fernández Simón, Esther, Gallardo, Eduard, Gómez Gálvez, Pedro, Piñol Jurado, Patricia, Suárez Calvet, Xavier   +6 more
core   +1 more source

The Effect of Microfluidic Geometry on Myoblast Migration

Micromachines, 2019
In vitro systems comprised of wells interconnected by microchannels have emerged as a platform for the study of cell migration or multicellular models.
Rahul Atmaramani, Bryan J. Black, Kevin H. Lam, Vinit M. Sheth, Joseph J. Pancrazio, David W. Schmidtke, Nesreen Zoghoul Alsmadi   +6 more
doaj   +1 more source

Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. [PDF]

, 2001
Long-term expression of coagulation factor IX (FIX) has been observed in murine and canine models following administration of recombinant adeno-associated viral (rAAV) vectors into either the portal vein or muscle. These studies were designed to evaluate
Davidoff, A, Hanawa, H, Nathwani, AC, Nienhuis, AW, Vanin, EF, Zhou, JF   +5 more
core   +1 more source

POLB Regulates Proliferation and Apoptosis of Bovine Primary Myocytes

Animals
DNA polymerase β (DNA polymerase beta (POLB)) belongs to a member of the DNA polymerase X family, mainly involved in various biological metabolic processes, such as eukaryotic DNA replication, DNA damage repair, gene recombination, and cell cycle ...
Geyang Zhang, Jiamei Wang, Yulong Li, Zijing Zhang, Xiangnan Wang, Fuying Chen, Qiaoting Shi, Yongzhen Huang, Eryao Wang, Shijie Lyu   +9 more
doaj   +1 more source

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro

BMC Cardiovascular Disorders, 2006
Background Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy.
Kienast Yvonne, Ullrich Nina D, MacLeod Kenneth T, Spohr Hilmar, Patel Pravina, Themis Michael, Ma Yu-Ling, Tolmachov Oleg, Coutelle Charles, Peters Nicholas S   +9 more
doaj   +1 more source

Herculin, a Fourth Member of the MyoD Family of Myogenic Regulatory Genes [PDF]

, 1990
We have identified and cloned herculin, a fourth mouse muscle regulatory gene. Comparison of its DNA and deduced amino acid sequences with those of the three known myogenic genes (MyoD, myogenin, and Myf-5) reveals scattered short spans with similarity ...
Miner, Jeffrey H., Wold, Barbara J.
core   +1 more source

Ion‐Permeable Electrospun Scaffolds Enable Controlled In‐Vitro Electrostimulation Assay of Myoblasts

Advanced Materials Interfaces
In‐vitro models are fundamental for studying muscular cell contractility and for wide‐screening of therapeutic candidates targeting skeletal muscle diseases, owing to their scalability, reproducibility, and circumvention of ethical concerns.
Serafina Pacilio, Francesco Decataldo, Roberta Costa, Tobias Cramer, Beatrice Fraboni, Giovanna Cenacchi, Maria Letizia Focarete   +6 more
doaj   +1 more source

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]

, 2014
Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre, Antonescu, Bain, Boppart, Cancello, Cao, Carlson, Caroline P. Wheeler-Jones, Cazzolli, Chavez, Cleasby, Coll, Corraliza, de Alvaro, De Paepe, Devaraj, Diamond-Stanic, Dimopoulos, Elgazar-Carmon, Festa, Fink, Fujishiro, Gao, Griffin, Haversen, Hemi, Hevener, Hirabara, Hirosumi, Hoehn, Hommelberg, Hotamisligil, Hotamisligil, Hwang, Kadotani, Karten, Kewalramani, Kuma, Lee, Lee, Liang, Lumeng, Lumeng, Maekawa, Mark E. Cleasby, McCall, Nguyen, Nicola A. Talbot, Patel, Pillon, Pinnick, Plomgaard, Polkinghorne, Prieur, Samokhvalov, Schilling, Sell, Shi, Solinas, Storlien, Suganami, Tardif, Thong, Turner, Uysal, Varma, Weisberg, Yuan   +67 more
core   +2 more sources

Enzyme prodrug therapy achieves site-specific, personalized physiological responses to the locally produced nitric oxide [PDF]

, 2018
Nitric oxide (NO) is a highly potent but short-lived endogenous radical with a wide spectrum of physiological activities. In this work, we developed an enzymatic approach to the site-specific synthesis of NO mediated by biocatalytic surface coatings ...
Alexander N. Zelikin, Anna K. Winther, Betina Fejerskov, Jeremy E. Schaffer, Kerdjoudj H., Leo J. Schultze Kool, Marja ter Meer, Molly M. Stevens, Moncada S., Najah B.S. Jensen, Rona Chandrawati, Ross Dillion, Ulf Simonsen   +12 more
core   +2 more sources

c-Myb Inhibits Myoblast Fusion

PLoS ONE, 2013
Satellite cells represent a heterogeneous population of stem and progenitor cells responsible for muscle growth, repair and regeneration. We investigated whether c-Myb could play a role in satellite cell biology because our previous results using satellite cell-derived mouse myoblast cell line C2C12 showed that c-Myb was expressed in growing cells and ...
Petr Kaspar, Kristina Ilencikova, Martina Zikova, Ondrej Horvath, Vladimir Cermak, Petr Bartunek, Hynek Strnad   +6 more
openaire   +4 more sources