Results 211 to 220 of about 78,749 (287)

Acute Cold Exposure Cell-Autonomously Reduces mTORC1 Signaling and Protein Synthesis Independent of AMPK. [PDF]

Cells
Sung BY, Ford EJ, Foster DJ, Fullmer KJ, Cromwell C, Viollet B, Thomson DM.   +6 more
europepmc   +1 more source

Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell‐Based Therapies

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Graphical presentation of stem cell‐based therapies for arterial dysfunction, endothelial repair and regeneration strategies. SMC, smooth muscle cell. ABSTRACT Arterial regeneration represents a critical frontier in cardiovascular medicine, as progressive endothelial dysfunction, maladaptive vascular smooth muscle cell (SMC) plasticity, and chronic ...
Yun‐Yu Ma, Shu‐Yao Zhu, Yi Song
wiley   +1 more source

GMPPB-CDG Results in Lysosomal Dysfunction and Acid Alpha-Glucosidase Deficiency. [PDF]

J Inherit Metab Dis
Damiano C, Tarallo A, Gragnaniello V, Strollo S, Fecarotta S, Tuzzi MR, Polishchuk E, Montefusco S, Valanzano A, Assunto A, Minopoli N, Casa RD, Polishchuk R, Groen SLMI', Medina DL, Bertini E, Carrozzo R, Emmerich J, Schoser B, Pijnappel WWMP, Parenti G.   +20 more
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion. [PDF]

Nat Commun
Zhang H, Shang R, Zhang Z, Zhou M, Bigot A, Cai Y, Zhao Y, Wang Y, Deshmukh A, Kudryashova E, Kudryashov DS, He C, Mouly V, Bi P.   +13 more
europepmc   +1 more source

Effect of post‐harvest ultrasound treatment on phytochemical enhancement in Gynura procumbens leaves and their protection against oxidative stress‐induced muscle atrophy

Journal of the Science of Food and Agriculture, Volume 106, Issue 4, Page 2270-2279, 15 March 2026.
Abstract BACKGROUND Gynura procumbens is a medicinal plant widely recognized for its antioxidant and anti‐inflammatory properties. Despite its traditional use in Southeast Asia, its potential role in promoting muscle health has not been thoroughly investigated.
Taemin Jeong, Seonghwa Hong, Jeehye Sung, Heon‐Sang Jeong, Hana Lee, Junsoo Lee   +5 more
wiley   +1 more source

Major Royal Jelly Proteins promote C2C12 myotubes differentiation by improving mitochondrial function. [PDF]

Front Nutr
Zhang X, Wei J, Liao S, Huang L, Bai Z, Hu Y, Yang C, Zhong B, Gu Y, Li B, Wang J.   +10 more
europepmc   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Investigating the role of EGFR signalling in muscle dystrophies: implications for Duchenne muscular dystrophy. [PDF]

Cell Death Dis
Fernández-Simón E, Tejedera-Villafranca A, Fernández-Garabay X, Clark J, Monceau A, Villalobos E, Cox D, Azcón JR, Fernández-Costa JM, Manera JD.   +9 more
europepmc   +1 more source

Cancer‐associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi‐omics and machine learning analysis

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. This study investigated the impact of histologically unique activated cancer‐associated fibroblasts (aCAFs) on survival outcomes and immune responses and examined their association with various ...
Myungsun Shim, One‐Zoong Kim, Byoung Kwan Son, Jung Ki Jo, Seung Wook Lee, Hong Sang Moon, Hyung Suk Kim, Mi Jung Kwon, Sung Hak Lee, Yung‐Kyun Noh, Kyueng‐Whan Min   +10 more
wiley   +1 more source