Results 221 to 230 of about 79,476 (305)

METTL16-m⁶A-PGC-1α axis contributes to exercise-induced mitochondrial adaptations in skeletal muscle of high-fat diet-fed insulin-resistant mice. [PDF]

BMC Biol
Chen C, Jiang C, Xiang Q, Hu Y, Wu H, Huang C, Zhou H, Xu Y, Hou M, Liu W, Han X.   +10 more
europepmc   +1 more source

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

ATRA influences the differentiation and fusion of myoblasts by regulating Rarα/Pitx2, leading to abnormal development of the pelvic floor muscles (PFMs) in fetal rats. [PDF]

PLoS One
Zhao H, Cao J, Mu H, Bi Y, Guo Z, Shi Y, Wang Y.   +6 more
europepmc   +1 more source

Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab‐binding domain

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TBC (Tre2/Bub2/Cdc16) domain‐containing proteins constitute the widespread family of GTPase‐activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. TBC1D17, involved in Shiga toxin trafficking, autophagy and glucose metabolism regulation, constitutes an ...
Dominika Nielipińska, Marta Orlikowska, Maciej Nielipiński, Bartosz Sekuła, Katarzyna M. Błażewska, Edyta Gendaszewska‐Darmach, Agnieszka J. Pietrzyk‐Brzezińska   +6 more
wiley   +1 more source

Cytohesin-2 is essential for the perinatal development of mice and regulates Golgi volume. [PDF]

Life Sci Alliance
Küsters C, Jux B, Shakeri F, Kallabis S, Meissner F, Kolanus W.   +5 more
europepmc   +1 more source

Shear‐Induced Anisotropic Supramolecular Gel Noodles for Improved Cell Guidance in Polarized Tissue Engineering

Small, Volume 22, Issue 26, 8 May 2026.
A simple two‐stage extrusion aligns supramolecular fibrils into 1D gel noodles. The residual pressure in the viscous pre‐gel drives the formation of a thin filament that is locked by Ca2+ cross‐linker into a highly anisotropic segment. The aligned noodles show enhanced tensile strength and guide myoblast elongation along the fiber, mimicking aligned ...
Dipankar Ghosh, Matthew Walker, Lauren Matthews, Charlie Patterson, Oana Dobre, Massimo Vassalli, Dave J. Adams   +6 more
wiley   +1 more source

The matricellular protein CCN5 (WISP2) inhibits cellular senescence in cardiac myoblasts and fibroblasts. [PDF]

Sci Rep
Jo Y, Lee M, Kim SB, Kwak TH, Jeong D, Jang SP, Park WJ.   +6 more
europepmc   +1 more source

Ageing‐Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1‐Meditated Ca2+ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice

Cell Proliferation, Volume 59, Issue 5, May 2026.
During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi, Yusheng Zhang, Gong Chen, Jiru Zhang, Jing Liu, Hao Zhu, Minne Sun, Yu Duan   +7 more
wiley   +1 more source

Acute Cold Exposure Cell-Autonomously Reduces mTORC1 Signaling and Protein Synthesis Independent of AMPK. [PDF]

Cells
Sung BY, Ford EJ, Foster DJ, Fullmer KJ, Cromwell C, Viollet B, Thomson DM.   +6 more
europepmc   +1 more source

Mechanobiology in Stem Cell‐Based Bioprinting

Cell Proliferation, Volume 59, Issue 5, May 2026.
Mechanobiology in stem cell‐based bioprinting is an emerging field that bridges the mechanical conditions of the bioprinting process with the regulation of stem cell behaviour for engineering living tissues. Stresses encountered during bioprinting, together with the mechanical properties of bioinks, play a critical role in regulating stem cell ...
Supeng Ding, Tiankun Liu, Rui Yao
wiley   +1 more source