Results 201 to 210 of about 54,075 (312)

A Primate‐Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1‐Dependent Destabilization of RBMX

Aging Cell, Volume 25, Issue 7, July 2026.
Primate‐specific lncRNA LINC01021 promotes aging by enhancing cellular senescence and accelerating aspects of organismal decline. Mechanistically, LINC01021 induces DAZAP1‐mediated destabilization of RBMX, activating the P53 pathway and establishing a primate‐specific regulatory axis in aging.
Yan Zhang, Li Hu, Xin Dong, Qinghua Zeng, Meiting Zi, Ayesha Nisar, Sawar Khan, Raoxian Bai, Chonghui Liu, Mingxia Ge, Shaoyan Pu, Gonghua Li, Yonghan He   +12 more
wiley   +1 more source

FURIN Stimulates NOTCH2 and NOTCH3 Pathways, Leading to Return of Function in Aged Cells. [PDF]

Life (Basel)
Elkin PL, Liu J, Wheeler JT, Suchyna TM, Hofmann WA.   +4 more
europepmc   +1 more source

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype. [PDF]

Orphanet J Rare Dis
Leoni C, Viscogliosi G, Pajalunga D, Trevisan V, Mondelli L, Angeli ML, Gullì C, Tatti M, Perri L, Bellani I, Lentini N, Pastorino R, Kuczynska E, Gervasoni J, Romeo DMM, Pane M, Mercuri EM, Cecchetti S, Carpentieri G, Tartaglia M, Zampino G, Flex E.   +21 more
europepmc   +1 more source

Positive and Negative Cardiovascular Effects of JAK Inhibitors in Inflammation

ACR Open Rheumatology, Volume 8, Issue 6, June 2026.
Chronic inflammation, characteristic of many autoimmune diseases, such as rheumatoid arthritis (RA), or myeloproliferative neoplasms (MPNs), is an independent driver of accelerated cardiovascular (CV) risk, primarily through proinflammatory cytokines that induce atherosclerosis and endothelial dysfunction.
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence. [PDF]

J Cachexia Sarcopenia Muscle
Park SJ, Baek JY, Wei S, Lee JY, Lee Y, Lee SH, Jang IY, Sakong H, Yoo HJ, Jung HW, Lee E, Kim SJ, Jo Y, Kim K, Ryu D, Kim BJ.   +15 more
europepmc   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

Quercetin attenuates deoxynivalenol-induced muscle developmental disorders in broilers by modulating the PI3K/Akt/mTOR pathway and reducing apoptosis. [PDF]

Poult Sci
Fang Y, Fu H, Jiang X, Yang H, Yin Y, Li B, Chen X, Shi B, Cai J, Zhang Z.   +9 more
europepmc   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source