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Neuromuscular Disorders, 2002
Myoblast transplantation was the first quasi-gene therapy to be suggested for Duchenne muscular dystrophy. Animal experiments established the principles that the missing gene could be targeted to muscle by grafting of genetically normal myoblasts that were able to repair the disease-damaged muscle fibres.
Daniel Skuk, Jacques P. Tremblay
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Myoblast transplantation was the first quasi-gene therapy to be suggested for Duchenne muscular dystrophy. Animal experiments established the principles that the missing gene could be targeted to muscle by grafting of genetically normal myoblasts that were able to repair the disease-damaged muscle fibres.
Daniel Skuk, Jacques P. Tremblay
openaire +3 more sources
Myoblasts, Satellite Cells, and Myoblast Transfer
1990The prospects for introducing “foreign” nuclei through the cell fusion process have been considered since it first became clear that skeletal muscle fibers form by fusion of many mononucleated myoblasts rather than the proliferation of skeletal muscle nuclei within fibers (Stockdale and Holtzer, 1961).
F E, Stockdale +3 more
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Rapid death of injected myoblasts in myoblast transfer therapy
Muscle & Nerve, 1996Myoblast transplantation has been proposed as a potential therapy for Duchenne muscular dystrophy (DMD). A Y-chromosome-specific probe was used to track the fate of donor male myoblasts injected into dystrophic muscles of female mdx mice (which are an animal model for DMD).
Y, Fan +3 more
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Myoblast differentiation in vitro: Morphological differentiation of mononucleated myoblasts
Developmental Biology, 1976Abstract Phospholipase C from Clostridium perfringens has been shown previously to inhibit the fusion of cultured chick myoblasts without affecting recognition or cell cycle parameters. In this paper we report that the mononucleated myoblasts, in phospholipase C, synthesize thick and thin filaments and organize them into myofibrils, and that T ...
J A, Trotter, M, Nameroff
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