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Myoblast transplantation in inherited myopathies
1993Amongst the different forms of disease of human skeletal muscle are those where the lesion and subsequent pathological state is manifest within the muscle tissue itself: these are termed primary myopathies. Within this group are the muscular dystrophies, in which there is progressive degenerative wasting of striated musculature.
J E, Morgan, D J, Watt
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Cell Death in Myoblasts and Muscles
2009One of the hallmarks of development is that many more cells are produced than are ultimately needed for organogenesis. In the case of striated skeletal muscle, large numbers of myoblasts are generated in the somites and then migrate to take up residence in the limbs and the trunk.
Lawrence M, Schwartz +4 more
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Skeletal Myoblasts as a Therapeutic Agent
Progress in Cardiovascular Diseases, 2007Cell transplantation is emerging as a new treatment designed to improve the poor outcome of patients with cardiac failure. Its rationale is that implantation of contractile cells into postinfarction scars could functionally rejuvenate these areas. Primarily for practical reasons, autologous skeletal myoblasts have been the first to be considered for a ...
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Chromatin Immunoprecipitation in Skeletal Myoblasts
2018Chromatin immunoprecipitation (ChIP) is a powerful and sensitive technique that is widely used to study DNA-protein interactions. It enables an unbiased genome-wide analysis of transcriptional changes during several biological processes including cellular differentiation.
Vinay Kumar, Rao +2 more
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The origin of myoblasts and the problem of dedifferentiation
Experimental Cell Research, 1963Abstract Skeletal muscle of dystrophic mice was injured, thymidine- 3 H was administered and the mice were left for a period of 10 to 27 days to allow the regeneration of muscle fibers which would then contain many radioactive nuclei. When the muscle was reinjured, it was shown by radioautography that the newly regenerating fibers also contained many
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Myoblast transfer in heart failure
Surgical Clinics of North America, 2004In conclusion, myoblast transfer has now reached a stage where large randomized trials such as the one we are initiating (300 patients) are mandatory to thoroughly assess the efficacy of the procedure. It is important that the design of these studies complies with the stringent methodologic guidelines commonly used in drug trials, as this is the only ...
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[Study of myoblast culture and myoblast transfer therapy in dystrophic mice].
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences, 1995In this report, we study the suitable conditions for myoblast cultures through analysis of myoblast growth and differentiation, and then try to develop a mouse model for myoblast transfer therapy (MTT). Recently, some research has indicated that Muscular Dystrophy Murine Mice (MDX) have an X-linked recessive dystrophin deficiency which is caused by ...
H J, Jong +3 more
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