FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity
Advanced Science, EarlyView.Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li +11 more
wiley +1 more source
Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
Advanced Science, EarlyView.The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng +10 more
wiley +1 more source
Myocardial Oxygen Consumption as Influenced by Isotonic Contractions.
Experimental Biology and Medicine, 1962 SummaryOxygen consumption of non-stimulated trabeculae carneae, which were maintained at various resting tensions, was not increased when they were stimulated to contract isotonically at a frequency of one per second. The data further indicate that the aerobic metabolism of heart muscle was uninfluenced by resting tensions comparable to those in vivo.
openaire +3 more sources
Advanced Science, EarlyView.Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao +18 more
wiley +1 more source
Biomolecular Basis for Cold-Induced Contraction of Coronary Arteries in the Newborn Lamb: Implication in Myocardial Dysfunction after Hypothermic Cardiopulmonary Bypass ♦ 98 [PDF]
, 1998 Nagib Dahdah +2 more
openalex +1 more source
Advanced Science, EarlyView.Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan +16 more
wiley +1 more source
Wearable Image‐Based Colorimetric Sensor for Real‐Time Gas Detection with High Chromaticity
Advanced Electronic Materials, EarlyView.Flexible colorimetric gas sensing offers energy‐free operation, intuitive feedback, and stability against environmental changes. This study presents a resonator‐based sensor integrated with polyvinyl alcohol (PVA) on a flexible substrate, achieving nearly full RGB coverage and angular robustness up to 60°.
Ji‐Eun Yeo +3 more
wiley +1 more source
Assessment of left ventricular long axis contraction can detect early myocardial dysfunction in asymptomatic patients with severe aortic regurgitation [PDF]
, 2001 Dragoş Vinereanu
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Short‐ and Long‐Term Outcomes of Open, Laparoscopic, and Robot‐Assisted Surgery for Rectal Cancer
Annals of Gastroenterological Surgery, EarlyView.Robot‐assisted rectal resection demonstrated superior short and long‐term outcomes compared to laparoscopic and open approaches. ABSTRACT Background Robot‐assisted surgery has short‐term benefits in rectal cancer surgery; however, its long‐term advantages remain unclear. This study compared short‐ and long‐term outcomes of open, laparoscopic, and robot‐
Marie Hanaoka +8 more
wiley +1 more source
Full recovery of contraction late after acute myocardial infarction: determinants and early predictors [PDF]
, 2001 Patrizio Lancellotti +3 more
openalex +1 more source