Results 121 to 130 of about 60,797 (160)

The role of the autophagy in myocardial ischemia/reperfusion injury

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2015
Autophagy is an intracellular process responsible for damaged or unnecessary protein and organelle degradation. In the heart, autophagy occurs at basal level and dysregulated autophagy is associated with a variety of cardiovascular diseases. Autophagy is enhanced in ischemia as well as in the reperfusion phase during cardiac ischemia reperfusion (I/R ...

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Connexin43 and Myocardial Ischemia-Reperfusion Injury

Cardiovascular & Hematological Disorders-Drug Targets, 2018
Recently, the treatment and prevention of ischemic cardiomyopathy is one of the emerging research topics in the cardiovascular field. Gap junction is the basic structure of cardiac electrophysiology. Connexin is the basic unit of gap junctions. Connexin43(CX43) is the most abundant member of Cx family in the heart, the normal expression of Cx43 is ...
Lingyun, Zu, Ningxin, Wen, Changjie, Liu, Mingming, Zhao, Lemin, Zheng   +4 more
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Zinc and myocardial ischemia/reperfusion injury

BioMetals, 2013
As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors.
Zhelong, Xu, Juan, Zhou
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Clarithromycin attenuates myocardial ischemia–reperfusion injury

Expert Opinion on Therapeutic Targets, 2010
MMP activity is upregulated in the heart after myocardial ischemia reperfusion, and its activation contributes to the changes in left ventricular (LV) dysfunction. A major macrolide antibiotic, clarithromycin has many biological functions including MMP regulation.
Takuya, Nakajima, Keiichi, Hishikari, Masahito, Ogawa, Ryo, Watanabe, Jun-ichi, Suzuki, Ayako, Nagashima, Mayumi, Masumura, Kiyoshi, Takayama, Yasunobu, Hirata, Ryozo, Nagai, Mitsuaki, Isobe   +10 more
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The Protective of Baicalin on Myocardial Ischemia-Reperfusion Injury

Current Pharmaceutical Biotechnology, 2020
Background:The aim of this study was to explore the inhibitory effect of baicalin on myocardial apoptosis induced by Ischemia-Reperfusion (I/R).Methods:Sprague Dawley rats' heart and myocardial cells I/R model were established in vivo and vitro, then 100 mg/kg and 10 μmol/l baicalin were administrated, respectively.
Xiaoli Liu, Shanshan Zhang, Chaoyue Xu, Yongchao Sun, Shujian Sui, Zhaohua Zhang, Yun Luan   +6 more
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Lymphocyte Communication in Myocardial Ischemia/Reperfusion Injury

Antioxidants and Redox Signaling, 2017
Significance: Myocardial ischemia/reperfusion (I/R) is an important complication of reperfusion therapy for myocardial infarction (MI). It is a complex process involving metabolic and immunological factors. To date, no effective treatment has been identified.
Ioakim Spyridopoulos, Emanuele Andreano   +1 more
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Complement inhibitors in myocardial ischemia/reperfusion injury

Immunopharmacology, 1997
Myocardial ischemia/reperfusion injury is accompanied by an inflammatory response contributing to reversible and irreversible changes in tissue viability and organ function. Endothelial and leukocyte responses are involved in tissue injury, orchestrated primarily by the complement cascade.
B R, Lucchesi, K S, Kilgore
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Perioperative myocardial ischemia reperfusion injury

Anesthesiology Clinics of North America, 2003
Myocardial I-R injury contributes to adverse cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation, coordination, and amplification of several systemic and local proinflammatory pathways (Fig. 4).
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Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Journal of Visualized Experiments, 2022
Acute myocardial infarction is a common cardiovascular disease with high mortality. Myocardial reperfusion injury can counteract the beneficial effects of heart reflow and induce secondary myocardial injury. A simple and reproducible model of myocardial infarction and myocardial ischemia-reperfusion injury is a good tool for researchers.
Bingjie, Lv, Jin, Zhou, Shaolin, He, Yuqi, Zheng, Wenlin, Yang, Shangwei, Liu, Chengxing, Liu, Boyuan, Wang, Dazhu, Li, Jibin, Lin   +9 more
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C5aR-mediated myocardial ischemia/reperfusion injury

Biochemical and Biophysical Research Communications, 2007
The complement system activation can mediate myocardial ischemia and reperfusion (I/R). Inhibition of C5a activity reveals attenuation of I/R-induced myocardial infarct size. However, the contribution of C5a receptor (C5aR) to I/R injury remains to be unknown.
Haimou, Zhang, Gangjian, Qin, Gang, Liang, Jinan, Li, Robert A, Barrington, Dong-Xu, Liu   +5 more
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