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Myocardial Ischemia Reperfusion Injury [PDF]

open access: yesSeminars in Cardiothoracic and Vascular Anesthesia, 2012
Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after myocardial ischemia, cardiac surgery or circulatory arrest. Primarily, no blood flow to the heart causes an imbalance between oxygen demand and supply, named ischemia (from the Greek isch, restriction; and haema, blood), resulting in damage or dysfunction of the
Michael Koeppen   +2 more
exaly   +5 more sources

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

open access: yesJournal of the American College of Cardiology, 2015
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2 processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the last 3 decades, therapies to reduce ischemic injury (mainly reperfusion strategies) have been widely incorporated into clinical practice.
Gerd Heusch   +2 more
exaly   +4 more sources
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Purinergic signaling in myocardial ischemia–reperfusion injury

Purinergic Signalling, 2022
Purines and their derivatives, extensively distributed in the body, act as a class of extracellular signaling molecules via a rich array of receptors, also known as purinoceptors (P1, P2X, and P2Y). They mediate multiple intracellular signal transduction pathways and participate in various physiological and pathological cell behaviors.
Yi, Zhuang, Mei-Ling, Yu, Sheng-Feng, Lu
openaire   +2 more sources

Peroxynitrite in Myocardial Ischemia-Reperfusion Injury

Heart Failure Reviews, 2002
Peroxynitrite is a highly reactive oxidant which is produced during reperfusion of the ischemic heart. The role that this molecule plays in reperfusion injury has been controversial. Many investigations have demonstrated toxic effects of peroxynitrite, whereas others have found it to be protective during reperfusion.
Manoj M, Lalu   +2 more
openaire   +2 more sources

The Role of P53 in Myocardial Ischemia-Reperfusion Injury

Cardiovascular Drugs and Therapy, 2023
P53 is one of the key tumor suppressors. In normal cells, p53 is maintained at low levels by the ubiquitination of the ubiquitinated ligase MDM2. In contrast, under stress conditions such as DNA damage and ischemia, the interaction between p53 and MDM2 is blocked and activated by phosphorylation and acetylation, thereby mediating the trans-activation ...
Xi-zi Zhu   +5 more
openaire   +2 more sources

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