Results 91 to 100 of about 106,495 (306)

The Role of Exosomes in Myocardial Ischemia-Reperfusion Injury

Cardiology
Background: Acute myocardial infarction (AMI) is one of the critical and serious diseases in the cardiovascular system, and reperfusion therapy is the preferred treatment for AMI, but it often worsens cardiac injury and leads to myocardial ischemia-reperfusion injury (MIRI), which can further result in arrhythmia, heart failure, and death.
Jingtao, Xu, Yu, Gao, Lili, Song, Jingtao, Xu, Hangshun, Li   +4 more
openaire   +3 more sources

Myocardial ischemia, reperfusion and free radical injury [PDF]

The American Journal of Cardiology, 1990
Reperfusion of coronary arteries to limit myocardial ischemic injury and extent of myocardial necrosis is possible by either the use of fibrinolytic therapy, coronary angioplasty or coronary artery bypass surgery. The concept that early reperfusion may salvage jeopardized myocardium is derived from basic experimental studies which purported to ...
openaire   +3 more sources

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Knockdown of Sfrp4 attenuates apoptosis to protect against myocardial ischemia/reperfusion injury

Journal of Pharmacological Sciences, 2019
Secreted frizzled-related protein (Sfrp) 4 is a protein that involve in cardiac development and several cardiovascular diseases. However, the effect of Sfrp4 in mediating myocardial ischemia/reperfusion injury remains unknown.
Wenhui Zeng, Yu Cao, Wanli Jiang, Ganjun Kang, Jie Huang, Songping Xie   +5 more
doaj   +1 more source

Mechanisms of Volatile Anesthetic-Induced Myocardial Protection [PDF]

, 2003
Volatile anesthetics protect myocardium against reversible and irreversible ischemic injury. Experimental evidence from several in vitro and in vivo animal models demonstrates that volatile agents enhance the recovery of stunned myocardium and reduce the
Gu, Weidong, Kersten, Judy R., LaDisa, John F., Ludwig, Lynda M., Pagel, Paul S., Tanaka, Katsuya, Warltier, David C.   +6 more
core   +1 more source

The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]

, 2012
This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L, Krafft, Paul R, Leitzke, Arthur S, Tang, Jiping, Van Allen, Nicole R, Zhang, John H   +5 more
core   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI). [PDF]

, 2014
AIM: Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI.
A. de Belder, A. Hannah, A. McDonald, A. Stewart, A. Struthers, B. Jagpal, Bolli, C. Lang, C. Neil, C. Neil, D. Dawson, D. Dawson, D. Garg, D. Hildick-Smith, D. Hildick-Smith, D. Hogg, D. Roy, E. Jansen, E. Roberts, E. Slattery, F. Gonzalvez, Flett, G. MacLennan, G. MacLennan, G. McPherson, Gori, H. Dargie, J. C. Kaski, J. Horowitz, J. Horowitz, J. Rhodes, J.-C. Kaski, K. Schwarz, L. Bennett, Lundberg, Lundberg, M. Black, M. Bruce, M. Bruce, M. Feelisch, M. Frenneaux, M. Frenneaux, M. Madhani, M. Metcalfe, Murillo, Murry, N. Awsan, N. Boon, N. Boon, N. Bunce, N. Cooter, N. Siddiqi, N. Siddiqi, P. Broadhurst, P. Nightingale, P. O. Lim, P. O. Lim, Piot, R. Bogle, R. Dautov, S. A. Papadopoulou, S. Brown, S. Cotton, S. Cotton, S. Firoozi, S. Papadopoulou, S. Rajendran, S. Singh, Shiva, Srihirun, T. Davidson, Tsang, W. Toff, White   +73 more
core   +3 more sources

Remote Ischemic Preconditioning Neither Improves Survival nor Reduces Myocardial or Kidney Injury in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI) [PDF]

, 2020
BACKGROUND: Peri-interventional myocardial injury occurs frequently during transcatheter aortic valve implantation (TAVI). We assessed the effect of remote ischemic preconditioning (RIPC) on myocardial injury, acute kidney injury (AKIN) and 6-month ...
Flechsig, Mandy, Heidrich, Felix M., Heinzel, Frank R., Ibrahim, Karim, Linke, Axel, Pfluecke, Christian, Quick, Silvio, Ruf, Tobias F., Strasser, Ruth H., Sveric, Krunoslav M., Troeger, Willi, Wiedemann, Stephan, Winzer, Robert, Youssef, Akram, Zhang, Kun   +14 more
core   +1 more source

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source