Results 71 to 80 of about 170,764 (299)

The Janus face of mitophagy in myocardial ischemia/reperfusion injury and recovery.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
In myocardial ischemia/reperfusion injury (MIRI), moderate mitophagy is a protective or adaptive mechanism because of clearing defective mitochondria accumulates during MIRI.
Jiaxin Deng, Qian Liu, Li-Ya Ye, Shuo Wang, Zhenyan Song, Mingyan Zhu, Fangfang Qiang, Yulin Zhou, Zhen Guo, Wei Zhang, Ting Chen   +10 more
semanticscholar   +1 more source

Therapeutic Peptides to Treat Myocardial Ischemia-Reperfusion Injury

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases (CVD) including acute myocardial infarction (AMI) rank first in worldwide mortality and according to the World Health Organization (WHO), they will stay at this rank until 2030.
Carlota Fernandez Rico, K. Konate, E. Josse, J. Nargeot, S. Barrère‐lemaire, P. Boisguérin   +5 more
semanticscholar   +1 more source

Protective Effect of Tetramethylpyrazine on Myocardial Ischemia‐Reperfusion Injury [PDF]

Evidence-Based Complementary and Alternative Medicine, 2014
Myocardial ischemia‐reperfusion injury (MIRI) is a common pathological and physiological phenomenon. Tetramethylpyrazine is the extract of the traditional Chinese medicine Chuanxiong, which can exert protective effects on MIRI in multiple ways.
Qian, Weidong, Xiong, Xingjiang, Fang, Zhuyuan, Lu, Haiting, Wang, Zhensheng   +4 more
openaire   +2 more sources

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To study the effect of fructose 1,6-diphosphate (FDP) on myocardial ischemia reperfusion injury in rats and its molecular mechanism. Methods: Male SPF SD rats were selected as experimental animals and randomly divided into four groups.
Ju-Fei Wang, Cheng Jiang
doaj   +1 more source

Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury

Nature Communications
Effective therapeutic strategies for myocardial ischemia/reperfusion (I/R) injury remain elusive. Targeting reactive oxygen species (ROS) provides a practical approach to mitigate myocardial damage following reperfusion.
Tianbao Ye, Cheng Chen, Di Wang, Chengjie Huang, Zhiwen Yan, Yu Chen, Xian Jin, Xiuyuan Wang, Xianting Ding, Chengxing Shen   +9 more
semanticscholar   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes

Nature Communications
Sleep disorders increase the risk and mortality of heart disease, but the brain-heart interaction has not yet been fully elucidated. Cuproptosis is a copper-dependent type of cell death activated by the excessive accumulation of intracellular copper ...
N. Chen, Lizhe Guo, Lu Wang, Sisi Dai, Xiaocheng Zhu, E. Wang   +5 more
semanticscholar   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cardioprotective Effect of SEA0400, a Selective Inhibitor of the Na+/Ca2+ Exchanger, on Myocardial Ischemia-Reperfusion Injury in Rats

Journal of Pharmacological Sciences, 2004
In this study, we investigated whether the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 (2-[4-[(2,5-difluorophenyl)methoxy]phenoxy-5-ethoxyaniline) might have a protective effect against myocardial ischemia-reperfusion injury in rats.
Minoru Yoshiyama, Yasuhiro Nakamura, Takashi Omura, Tetsuya Hayashi, Yasuhiro Takagi, Takao Hasegawa, Hiroki Nishioka, Kazuhide Takeuchi, Hiroshi Iwao, Junichi Yoshikawa   +9 more
doaj   +1 more source