Results 61 to 70 of about 170,764 (299)

Nitric oxide in myocardial ischemia/reperfusion injury [PDF]

Cardiovascular Research, 2004
Administration of nitric oxide (NO), NO donors or drugs that enhance NO release (statins, calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the myocardium against ischemia/reperfusion injury. While this exogenous administration of NO prior to ischemia can initiate a preconditioning-like phenomenon, endogenous NO-synthase ...
Rainer, Schulz, Malte, Kelm, Gerd, Heusch   +2 more
openaire   +2 more sources

Different types of cell death and their interactions in myocardial ischemia–reperfusion injury

Cell Death Discovery
Myocardial ischemia–reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow is restored to the heart tissue following ischemia-induced damage.
Bin Du, Qiang Fu, Qing Yang, Ye Yang, Rui Li, Xu Yang, Qing Yang, Shuo Li, Jinwei Tian, Huibin Liu   +9 more
semanticscholar   +1 more source

Long Noncoding RNAs in Myocardial Ischemia‐Reperfusion Injury

Oxidative Medicine and Cellular Longevity, 2021
Following an acute myocardial infarction, reperfusion therapy is currently the most effective way to save the ischemic myocardium; however, restoring blood flow may lead to a myocardial ischemia‐reperfusion injury (MIRI). Recent studies have confirmed that long‐chain noncoding RNAs (LncRNAs) play important roles in the pathophysiology of MIRIs.
Zhuo Zhao, Wei Sun, Ziyuan Guo, Bin Liu, Hongyu Yu, Jichang Zhang   +5 more
openaire   +2 more sources

Dexmedetomidine Ameliorates Myocardial Ischemia‐Reperfusion Injury by Inhibiting MDH2 Lactylation via Regulating Metabolic Reprogramming

Advancement of science
Myocardial ischemia‐reperfusion injury (MIRI) significantly worsens the outcomes of patients with cardiovascular diseases. Dexmedetomidine (Dex) is recognized for its cardioprotective properties, but the related mechanisms, especially regarding metabolic
Han She, Yi Hu, Guozhi Zhao, Yunxia Du, Yinyu Wu, Wei Chen, Yong Li, Yi Wang, Lei Tan, Yuanqun Zhou, Jie Zheng, Qinghui Li, Hong Yan, Qingxiang Mao, Deyu Zuo, Liangming Liu, Tao Li   +16 more
semanticscholar   +1 more source

The Safety and Efficacy of Intravascular Lithotripsy in the Treatment of Severe Coronary Artery Calcification in 261 Cases: A Retrospective Study

Health Science Reports
Background Coronary artery calcification is strongly linked to factors such as advanced age, dyslipidemia, and chronic kidney disease. Severe coronary artery calcification significantly elevates the complexity and risk of percutaneous coronary ...
Tiankun Wu, Honghui Yang, Guian Xu, Qingman Li, Lijie Zhu, Yapan Yang, Tingjie Yang   +6 more
doaj   +1 more source

Myocardial ischemia reperfusion injury is alleviated by curcumin-peptide hydrogel via upregulating autophagy and protecting mitochondrial function

Stem Cell Research & Therapy, 2021
Background Ischemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant cardioprotective effect against IRI, can inhibit ventricular remodeling induced by pressure load or MI ...
Chi-Lin Liao, Yang Liu, Meng-Zhao Huang, Hua-Yong Liu, Zi-Liang Ye, Qiang Su   +5 more
doaj   +1 more source

Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy

International Journal on Biological Sciences
This study investigated the mechanism by which NR4A1 regulates mitochondrial fission factor (Mff)-related mitochondrial fission and FUN14 domain 1 (FUNDC1)-mediated mitophagy following cardiac ischemia-reperfusion injury(I/R).
Junyan Wang, Haowen Zhuang, Lianqun Jia, Xinyong He, Sicheng Zheng, Kangshou Ji, K. Xie, Tong Ying, Ying Zhang, Chun Li, Xing Chang   +10 more
semanticscholar   +1 more source

ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy

Molecular Medicine, 2021
Aims Myocardial ischemia is the most common form of cardiovascular disease and the leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for the development of effective therapy. Therefore, this study aimed to investigate
Huimin Chen, Zezhou Xiao, Xiao Ling, Rongning Xu, P. Zhu, Shao-Yi Zheng   +5 more
semanticscholar   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source