Results 61 to 70 of about 106,495 (306)

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Cardioprotective Effect of SEA0400, a Selective Inhibitor of the Na+/Ca2+ Exchanger, on Myocardial Ischemia-Reperfusion Injury in Rats

Journal of Pharmacological Sciences, 2004
In this study, we investigated whether the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 (2-[4-[(2,5-difluorophenyl)methoxy]phenoxy-5-ethoxyaniline) might have a protective effect against myocardial ischemia-reperfusion injury in rats.
Minoru Yoshiyama, Yasuhiro Nakamura, Takashi Omura, Tetsuya Hayashi, Yasuhiro Takagi, Takao Hasegawa, Hiroki Nishioka, Kazuhide Takeuchi, Hiroshi Iwao, Junichi Yoshikawa   +9 more
doaj   +1 more source

Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice

Stem Cells International, 2023
Background. Obesity-related diseases have important implications for the occurrence, severity, and outcome of ischemic heart disease. Patients with obesity, hyperlipidemia, and diabetes mellitus (metabolic syndrome) are at increased risk of heart attack ...
Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang   +8 more
doaj   +1 more source

Role of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetes [PDF]

, 2013
Diabetes, characterized by hyperglycemia resulting from either insulin deficiency or insulin resistance, is a chronic metabolic disorder. Hearts of subjects with diabetes are more sensitive to myocardial ischemia/reperfusion injury but the underlying ...
Irwin, MG, LI, H, Li, Y, Tao, M, Xia, Z, Zhang, L   +5 more
core   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts [PDF]

, 2014
Aims: Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease.
A Beenken, A Kharitonenkov, A Planavila, A Romero-Corral, A Sharma, AD Attie, AK Bose, Bee K. Tan, BK Tan, C Valina, C Yang, D Morabito, DJ Hausenloy, DR Riddell, E Braunwald, Edward W. Hillhouse, Emilio Hirsch, FM Fisher, G Nanayakkara, GC Rodrigo, GD Lopaschuk, H Jiao, H Li, Harpal S. Randeva, J Diaz-Delfin, J Mair, J Yie, J Yie, Jing Chen, JP Bertinchant, L Timmers, LC Clavijo, M Mraz, Manjunath Ramanjaneya, MC Mendoza, Muhammad F. Bari, N Shimizu, PK Shah, R Adya, R Mitra, Raghu Adya, S Doroudgar, S Kenchaiah, S Yusuf, SQ Liu, SQ Liu, Sunil K. Bhudia, T Matsui, T Nishimura, T Thim, T Uebanso, V Lionetti, Vanlata Patel, Y Ogawa, Y Wang   +54 more
core   +3 more sources

Nanozymes at the Bio‐Nano Interface: From Synthesis, Defect Engineering, Catalytic Behavior in Biological Microenvironments, and Biosafety Implications

Advanced Materials Interfaces, EarlyView.
Nanozymes (NZs) have emerged as versatile artificial enzymes with tunable catalytic properties driven by atomic coordination, defect engineering, and surface chemistry. This review presents a bio–nano interface framework linking synthesis strategies, structural design, and catalytic behavior within complex biological microenvironments.
Karen Guadalupe Quintero‐Garrido, Aída Jimena Velarde‐Salcedo, Alejandro López‐Amador, Noé Arjona, Citlali Uitz Toalá, Carmen Gonzalez, Beatriz Liliana España‐Sánchez   +6 more
wiley   +1 more source

Mitochondrial Dynamics: An Attractive Therapeutic Target for Ischemia-Reperfusion Injury in the Heart

MCBS (Molecular and Cellular Biomedical Sciences)
Myocardial infarction is one of the leading causes of death worldwide. Current treatments do not compensate for the loss of cardiomyocytes, thus progression to heart failure is often inevitable.
Elisha Rosalyn Rosdah, Eka Febri Zulissetiana, Ayeshah Augusta Rosdah   +2 more
doaj   +1 more source

Detection of Myocardial Ischemia-Reperfusion Injury Using a Fluorescent Near-Infrared Zinc(II)-Dipicolylamine Probe and Tc Glucarate

Molecular Imaging, 2012
A fluorescent zinc 2,2′-dipicolylamine coordination complex PSVue®794 (probe 1) is known to selectively bind to phosphatidylserine exposed on the surface of apoptotic and necrotic cells.
Leonie wyffels, Brian D. Gray, Christy Barber, Koon Y. Pak, Safiyyah Forbes, Jeffrey A. Mattis, James M. Woolfenden, Zhonglin Liu   +7 more
doaj   +1 more source

A Novel Biological Strategy for Myocardial Protection by Intracoronary Delivery of Mitochondria: Safety and Efficacy

JACC: Basic to Translational Science, 2019
Summary: Mitochondrial dysfunction is the determinant insult of ischemia-reperfusion injury. Autologous mitochondrial transplantation involves supplying one’s healthy mitochondria to the ischemic region harboring damaged mitochondria. The authors used in 
Borami Shin, MD, Mossab Y. Saeed, MD, Jesse J. Esch, MD, Alvise Guariento, MD, David Blitzer, MD, Kamila Moskowitzova, MD, Giovanna Ramirez-Barbieri, MD, Arzoo Orfany, MD, Jerusha K. Thedsanamoorthy, BA, Douglas B. Cowan, PhD, James A. Inkster, PhD, Erin R. Snay, BRS, Steven J. Staffa, MS, Alan B. Packard, PhD, David Zurakowski, PhD, Pedro J. del Nido, MD, James D. McCully, PhD   +16 more
doaj   +1 more source