Results 51 to 60 of about 60,797 (160)

Detection of Myocardial Ischemia-Reperfusion Injury Using a Fluorescent Near-Infrared Zinc(II)-Dipicolylamine Probe and Tc Glucarate

Molecular Imaging, 2012
A fluorescent zinc 2,2′-dipicolylamine coordination complex PSVue®794 (probe 1) is known to selectively bind to phosphatidylserine exposed on the surface of apoptotic and necrotic cells.
Leonie wyffels, Brian D. Gray, Christy Barber, Koon Y. Pak, Safiyyah Forbes, Jeffrey A. Mattis, James M. Woolfenden, Zhonglin Liu   +7 more
doaj   +1 more source

Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice

Stem Cells International, 2023
Background. Obesity-related diseases have important implications for the occurrence, severity, and outcome of ischemic heart disease. Patients with obesity, hyperlipidemia, and diabetes mellitus (metabolic syndrome) are at increased risk of heart attack ...
Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang   +8 more
doaj   +1 more source

Mild therapeutic hypothermia upregulates the O-GlcNAcylation level of COX10 to alleviate mitochondrial damage induced by myocardial ischemia–reperfusion injury

Journal of Translational Medicine
Objective Mild therapeutic hypothermia (MTH) is an important method for perioperative prevention and treatment of myocardial ischemia–reperfusion injury (MIRI). Modifying mitochondrial proteins after protein translation to regulate mitochondrial function
Wei Deng, Yixuan Chen, Jing Zhang, Jitao Ling, Zhou Xu, Zicheng Zhu, Xiaoyi Tang, Xiao Liu, Deju Zhang, Hong Zhu, Haili Lang, Lieliang Zhang, Fuzhou Hua, Shuchun Yu, Kejian Qian, Peng Yu   +15 more
doaj   +1 more source

A Novel Biological Strategy for Myocardial Protection by Intracoronary Delivery of Mitochondria: Safety and Efficacy

JACC: Basic to Translational Science, 2019
Summary: Mitochondrial dysfunction is the determinant insult of ischemia-reperfusion injury. Autologous mitochondrial transplantation involves supplying one’s healthy mitochondria to the ischemic region harboring damaged mitochondria. The authors used in 
Borami Shin, MD, Mossab Y. Saeed, MD, Jesse J. Esch, MD, Alvise Guariento, MD, David Blitzer, MD, Kamila Moskowitzova, MD, Giovanna Ramirez-Barbieri, MD, Arzoo Orfany, MD, Jerusha K. Thedsanamoorthy, BA, Douglas B. Cowan, PhD, James A. Inkster, PhD, Erin R. Snay, BRS, Steven J. Staffa, MS, Alan B. Packard, PhD, David Zurakowski, PhD, Pedro J. del Nido, MD, James D. McCully, PhD   +16 more
doaj   +1 more source

The Hedgehog morphogen in myocardial ischemia–reperfusion injury

Experimental Biology and Medicine, 2010
The developmental Hedgehog (Hh) protein family is known to be pivotal in many embryonic patterning events and the number of processes in which Hh plays an essential role is expanding persistently. Recently, it has become clear that the Hh pathway is not only active in the developing embryo but also in the adult organism.
Maarten F, Bijlsma, C Arnold, Spek
openaire   +2 more sources

Role of cardiac renin angiotensin system in ischemia reperfusion injury and preconditioning of heart

Indian Heart Journal, 2016
Cardio-vascular diseases are the leading cause of morbidity and mortality. Ischemia is a state of oxygen deprivation in tissues, whereas reperfusion is restoration of blood flow in ischemic tissues.
Vimal Agrawal, Jeetendra Kumar Gupta, Shaiba Sana Qureshi, Vishal Kumar Vishwakarma   +3 more
doaj   +1 more source

The Role of Exosomes in Myocardial Ischemia-Reperfusion Injury

Cardiology
Background: Acute myocardial infarction (AMI) is one of the critical and serious diseases in the cardiovascular system, and reperfusion therapy is the preferred treatment for AMI, but it often worsens cardiac injury and leads to myocardial ischemia-reperfusion injury (MIRI), which can further result in arrhythmia, heart failure, and death.
Jingtao, Xu, Yu, Gao, Lili, Song, Jingtao, Xu, Hangshun, Li   +4 more
openaire   +3 more sources

Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review

Medicine Science, 2017
Myocardial ischemia/reperfusion injury is one of the main causes of morbidity and mortality in the world. This injury is experienced by patients suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing ...
Hakan Parlakpinar, Mehmet Hamdi Orum, Onural Ozhan   +2 more
doaj   +1 more source

Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice

Journal of Pharmacological Sciences, 2004
We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury.
Issei Komuro, Masashi Ohtsuka
doaj   +1 more source

Myocardial ischemia, reperfusion and free radical injury [PDF]

The American Journal of Cardiology, 1990
Reperfusion of coronary arteries to limit myocardial ischemic injury and extent of myocardial necrosis is possible by either the use of fibrinolytic therapy, coronary angioplasty or coronary artery bypass surgery. The concept that early reperfusion may salvage jeopardized myocardium is derived from basic experimental studies which purported to ...
openaire   +3 more sources