The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction [PDF]
, 2017 Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic
Budiono, Boris P +5 more
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Curcumin attenuates myocardial ischemia-reperfusion injury
Oncotarget, 2017 Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated.The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ...
Liu, Kun +8 more
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Phosphomimetic modulation of eNOS improves myocardial reperfusion and mimics cardiac postconditioning in mice. [PDF]
PLoS ONE, 2014 Myocardial infarction resulting from ischemia-reperfusion injury can be reduced by cardiac postconditioning, in which blood flow is restored intermittently prior to full reperfusion.
Terrence Pong +4 more
doaj +1 more source
Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]
, 2009 The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S +2 more
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Cardiac phospholipidome is altered during ischemia and reperfusion in an ex vivo rat model
Biochemistry and Biophysics Reports, 2021 Acute myocardial infarction (AMI) is the leading cause of death, morbidity, and health costs worldwide. In AMI, a sudden blockage of blood flow causes myocardial ischemia and cell death.
Javier-Fernando Montero-Bullon +8 more
doaj +1 more source
Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide (R) in isolated perfused rabbit hearts [PDF]
, 2008 The calpain inhibitor A-705253 and the Na(+)/H(+) exchange inhibitor Cariporide (R) were studied in isolated perfused rabbit hearts subjected to 60 min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first ...
Bardenheuer H. +19 more
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Platelet Contributions to Myocardial Ischemia/Reperfusion Injury [PDF]
Frontiers in Immunology, 2019 Obstruction of a coronary artery causes ischemia of heart tissue leading to myocardial infarction. Prolonged oxygen deficiency provokes tissue necrosis, which can result in heart failure and death of the patient. Therefore, restoration of coronary blood flow (reperfusion of the ischemic area) by re-canalizing the affected vessel is essential for a ...
Schanze, Nancy +2 more
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Sphingolipid therapy in myocardial ischemia–reperfusion injury [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2008 Sphingolipids are known to play a significant physiological role in cell growth, cell differentiation, and critical signal transduction pathways. Recent studies have demonstrated a significant role of sphingolipids and their metabolites in the pathogenesis of myocardial ischemia-reperfusion injury.
Susheel, Gundewar, David J, Lefer
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Effects of propofol pretreatment on myocardial cell apoptosis and SERCA2 expression in rats with hepatic ischemia/reperfusion [PDF]
Revista Brasileira de Anestesiologia, 2018 Introduction: Hepatic ischemia-reperfusion injury is a common pathophysiological process in liver surgery. Whether Propofol can reduce myocardial ischemia-reperfusion injury induced by hepatic ischemia-reperfusion injury in rats, together with related ...
Shuzhen Yu +9 more
doaj +4 more sources
Signal Transduction and Targeted Therapy, 2022 Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death.
Xiao-Hui Ma +10 more
doaj +1 more source