Myocardial protective effect by ulinastatin via an anti-inflammatory response after regional ischemia/reperfusion injury in an in vivo rat heart model [PDF]
Korean Journal of Anesthesiology, 2011 BackgroundUlinastatin has anti-inflammatory properties and protects organs from ischemia/reperfusion-induced injury. The aim of this study was to investigate whether ulinastatin provides a protective effect on a regional myocardial ischemia/reperfusion ...
Il-Woo Shin +7 more
doaj +1 more source
Acta Cirúrgica Brasileira, 2022 Purpose: The present study explored the role and mechanism involved in aprepitant-induced cardioprotective effects in rat model of ischemia-reperfusion injury.
Mei Qian, Yang Liu
doaj +1 more source
The meaning of different forms of structural myocardial injury, immune response and timing of infarct necrosis and cardiac repair [PDF]
, 2015 Although a decline in the all-cause and cardiac mortality rates following myocardial infarction (MI) during the past 3 decades has been reported, MI is a major cause of death and disability worldwide.
Bello, S +5 more
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ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury [PDF]
, 1997 Objective: Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the ...
Becker, Bernhard F. +6 more
core +1 more source
Modulation of Mitochondrial Bioenergetics in the Isolated Guinea Pig Beating Heart by Potassium and Lidocaine Cardioplegia: Implications for Cardioprotection [PDF]
, 2009 Mitochondria are damaged by cardiac ischemia/reperfusion (I/R) injury but can contribute to cardioprotection. We tested if hyperkalemic cardioplegia (CP) and lidocaine (LID) differently modulate mitochondrial (m) bioenergetics and protect hearts against ...
Aldakkak, Mohammed +5 more
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Status of myocardial antioxidants in ischemia–reperfusion injury [PDF]
Cardiovascular Research, 2000 Myocardial ischemia-reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium due to ischemia-reperfusion includes cardiac contractile dysfunction, arrhythmias as well as irreversible myocyte damage.
N S, Dhalla +3 more
openaire +2 more sources
Ferroptosis: Opportunities and Challenges in Myocardial Ischemia‐Reperfusion Injury [PDF]
Oxidative Medicine and Cellular Longevity, 2021 Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and excessive ROS accumulation, damaging the integrity of
Wei-kun Zhao +3 more
openaire +2 more sources
Novel roles of κ-opioid receptor in myocardial ischemia-reperfusion injury [PDF]
PeerJAcute heart attack is the primary cause of cardiovascular-related death worldwide. A common treatment is reperfusion of ischemic tissue, which can cause irreversible damage to the myocardium.
Wen Zhang +4 more
doaj +2 more sources
Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy [PDF]
, 2006 Background - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by loss of cardiomyocytes and their replacement by adipose and fibrous tissue.
Asimaki, A +11 more
core +1 more source
Frontiers in Pharmacology, 2021 Baicalin is a natural flavonoid glycoside that confers protection against myocardial ischemia/reperfusion (I/R) injury. However, its mechanism has not been fully understood.
Zhenyu Fan +4 more
doaj +1 more source