Results 11 to 20 of about 170,764 (299)

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

open access: yesJournal of the American College of Cardiology, 2015
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2 processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the last 3 decades, therapies to reduce ischemic injury (mainly reperfusion strategies) have been widely incorporated into clinical practice.
Borja Ibanez   +2 more
exaly   +5 more sources

The role of gut microbiota in myocardial ischemia-reperfusion injury [PDF]

open access: yesFrontiers in Cardiovascular Medicine
Myocardial ischemia-reperfusion injury denotes the pathological damage resulting from the restoration of blood flow and oxygen supply following acute coronary artery occlusion.
Xin Chen   +9 more
doaj   +4 more sources

'Myocardial Ischemia-Reperfusion Injury and the Influence of Inflammation.

open access: yesTrends in Cardiovascular Medicine, 2022
Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to ischemia in the corresponding myocardial territory which generally results in myocardial necrosis.
M. Algoet   +6 more
semanticscholar   +4 more sources

Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

open access: yesBioengineered, 2021
Ferroptosis is an important form of myocardial cell death in myocardial ischemia-reperfusion injury (MIRI). Naringenin (NAR), as a flavonoid, has a significant advantage in improving MIRI.
Shujun Xu, Bingxin Wu, Biying Zhong
exaly   +2 more sources

Myocardial Ischemia Reperfusion Injury [PDF]

open access: yesSeminars in Cardiothoracic and Vascular Anesthesia, 2012
Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after myocardial ischemia, cardiac surgery or circulatory arrest. Primarily, no blood flow to the heart causes an imbalance between oxygen demand and supply, named ischemia (from the Greek isch, restriction; and haema, blood), resulting in damage or dysfunction of the
Stephanie Bonney   +2 more
exaly   +5 more sources

Pyroptosis: Novel Targets in Molecular Mechanisms and Drug Therapy Research for Myocardial Ischemia Reperfusion Injury [PDF]

open access: yesReviews in Cardiovascular Medicine
Myocardial ischemia-reperfusion injury is a significant complication of reperfusion therapy and a primary cause of mortality in patients with acute myocardial infarction.
Dong Zhang   +6 more
doaj   +2 more sources

Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury [PDF]

open access: yesOxidative Medicine and Cellular Longevity, 2021
Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane ...
Wei-Kun Zhao   +3 more
semanticscholar   +3 more sources

Myocardial ischemia – reperfusion injury

open access: yesZaporožskij Medicinskij Žurnal, 2023
Aim. To summarize and broaden the idea about mechanisms of acute coronary insufficiency development and pathophysiological features of myocardial reperfusion injury.
S. V. Salo   +3 more
doaj   +4 more sources

Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1

open access: yesCell Death Discovery, 2022
Myocardial ischemia/reperfusion (I/R) injury is a complex pathological process that is still not fully understood. The oxidative stress response has a critical role in the occurrence and progression of myocardial ischemia/reperfusion injury.
Qiong Xu   +10 more
doaj   +2 more sources

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis

open access: yesFrontiers in Pharmacology, 2021
Baicalin is a natural flavonoid glycoside that confers protection against myocardial ischemia/reperfusion (I/R) injury. However, its mechanism has not been fully understood.
Zhenyu Fan   +4 more
doaj   +2 more sources

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