Results 271 to 280 of about 107,803 (293)

Clarithromycin attenuates myocardial ischemia–reperfusion injury

Expert Opinion on Therapeutic Targets, 2010
MMP activity is upregulated in the heart after myocardial ischemia reperfusion, and its activation contributes to the changes in left ventricular (LV) dysfunction. A major macrolide antibiotic, clarithromycin has many biological functions including MMP regulation.
Takuya, Nakajima, Keiichi, Hishikari, Masahito, Ogawa, Ryo, Watanabe, Jun-ichi, Suzuki, Ayako, Nagashima, Mayumi, Masumura, Kiyoshi, Takayama, Yasunobu, Hirata, Ryozo, Nagai, Mitsuaki, Isobe   +10 more
openaire   +2 more sources

Perioperative myocardial ischemia reperfusion injury

Anesthesiology Clinics of North America, 2003
Myocardial I-R injury contributes to adverse cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation, coordination, and amplification of several systemic and local proinflammatory pathways (Fig. 4).
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Sodium Nitroprusside Exacerbates Myocardial Ischemia–Reperfusion Injury

The Annals of Thoracic Surgery, 1997
The role of nitric oxide in myocardial ischemia-reperfusion is controversial. Although many studies claim that nitric oxide ameliorates reperfusion injury, others suggest that it exacerbates such injury, possibly through peroxynitrite production.
J T, Cope, D, Banks, V E, Laubach, O A, Binns, R C, King, R M, Richardson, K S, Shockey, C G, Tribble, I L, Kron   +8 more
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Ras inhibition attenuates myocardial ischemia–reperfusion injury

Biochemical Pharmacology, 2009
Myocardial injury, developed after a period of ischemia/reperfusion (I/R) results in the destruction of functional heart tissue, this being replaced by scar tissue. Intracellular signaling pathways mediating cardiomyocyte death are partially understood and involve the activation of Ras.
Rakefet, Pando, Yelena, Cheporko, Ronit, Haklai, Sofia, Maysel-Auslender, Gad, Keren, Jacob, George, Eyal, Porat, Alex, Sagie, Yoel, Kloog, Edith, Hochhauser   +9 more
openaire   +2 more sources

Complement inhibitors in myocardial ischemia/reperfusion injury

Immunopharmacology, 1997
Myocardial ischemia/reperfusion injury is accompanied by an inflammatory response contributing to reversible and irreversible changes in tissue viability and organ function. Endothelial and leukocyte responses are involved in tissue injury, orchestrated primarily by the complement cascade.
B R, Lucchesi, K S, Kilgore
openaire   +2 more sources

Lymphocyte Communication in Myocardial Ischemia/Reperfusion Injury

Antioxidants & Redox Signaling, 2017
Myocardial ischemia/reperfusion (I/R) is an important complication of reperfusion therapy for myocardial infarction (MI). It is a complex process involving metabolic and immunological factors. To date, no effective treatment has been identified. Recent Advances: Previous research has focused on the role of innate immune cells in I/R injury.
Boag SE, Andreano E, Spyridopoulos I
openaire   +3 more sources

Mitochondrial redox regulation and myocardial ischemia-reperfusion injury

American Journal of Physiology-Cell Physiology, 2022
Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cellular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by complexes I and III of the electron transport chain (ETC) and by the proton motive force (PMF), consisting of a ...
Chwen-Lih Chen, Liwen Zhang, Zhicheng Jin, Takhar Kasumov, Yeong-Renn Chen   +4 more
openaire   +2 more sources

Endoxin Antagonist Lessens Myocardial Ischemia Reperfusion Injury

Cardiovascular Drugs and Therapy, 2004
To elucidate whether endoxin is one of important factors involved in myocardial ischemia reperfusion (MIR) injury, the change of myocardial endoxin level was determined in rats with MIR injury model and the effects of anti-digoxin antiserum (ADA), an endoxin specific antagonist, on MIR injury were studied.MIR injury model was obtained by ligating left ...
Yong-Sheng, Ke, De-Guo, Wang, He-Gui, Wang, Shang-Yin, Yang   +3 more
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Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention

Microvascular Research, 2023
Cardiovascular diseases are one of the leading causes of mortality in developed countries. Among cardiovascular disorders, myocardial infarction remains a life-threatening problem predisposing to the development and progression of ischemic heart failure. Ischemia/reperfusion (I/R) injury is a critical cause of myocardial injury. In recent decades, many
Yang, Liu, Lei, Li, Zhen, Wang, Juan, Zhang, Zhou, Zhou   +4 more
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Calcium Antagonists and Experimental Myocardial Ischemia Reperfusion Injury

Journal of Cardiovascular Pharmacology, 1992
A number of previous studies have reported that administration of calcium antagonists reduces acute ischemic injury in a variety of experimental models. More recently, however, it has been suggested that the beneficial effects of reperfusing the ischemic myocardium might be blunted by the paradoxical occurrence of a specific form of reperfusion ...
AMBROSIO, Giuseppe, Villari B, Chiariello M.   +2 more
openaire   +3 more sources