Results 31 to 40 of about 100,863 (292)
Levosimendan attenuates suspension-reperfusion injury in isolated hearts of rat models [PDF]
Jichu yixue yu linchuangObjective To investigate the effect of levosimendan on the cyclic guanosine monophosphate-adenosin monophosphate synthase-interferon gene stimulating factor (cGAS-STING) signaling pathway during suspension-reperfusion in isolated rat myocardium. Methods
PANG Yunting, REN Xiaoshuang, BAO Han, MENG Fanqing, SHI Feng
doaj +1 more source
Myocardial protective effect by ulinastatin via an anti-inflammatory response after regional ischemia/reperfusion injury in an in vivo rat heart model [PDF]
Korean Journal of Anesthesiology, 2011 BackgroundUlinastatin has anti-inflammatory properties and protects organs from ischemia/reperfusion-induced injury. The aim of this study was to investigate whether ulinastatin provides a protective effect on a regional myocardial ischemia/reperfusion ...
Il-Woo Shin +7 more
doaj +1 more source
Balkan Medical Journal, 2023 Background: In myocardial ischemia-reperfusion injury, myocardial damage is aggravated when blood perfusion is restored in myocardial infarction. Ubiquitin-specific protease 11 (USP11), a deubiquitinating enzyme, could remove the ubiquitination of ...
Yunfei Zhang +4 more
doaj +1 more source
Modelling myocardial ischaemia and reperfusion
Progress in Biophysics and Molecular Biology, 1998 Substrate depletion and increased intracellular acidity are believed to underlie clinically important manifestations of myocardial ischaemia. Recent advances in measuring ion concentrations and metabolite changes have provided a wealth of detail on the processes involved.
F F, Ch'en +3 more
openaire +2 more sources
Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles
Advanced Functional Materials, EarlyView.Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati +2 more
wiley +1 more source
Improving reperfusion after myocardial infarction
BMJ, 1999 After fibrinolytic therapy for acute myocardial infarction full antegrade perfusion (TIMI 3 flow) at 90 minutes occurs in only 29-54% of patients,1 while reocclusion occurs in at least 12%, with increased morbidity and mortality.2 Fibrinolytic therapy may itself be prothrombotic through releasing clot bound thrombin, which in turn stimulates platelet ...
I B, Menown, A A, Adgey
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin +18 more
wiley +1 more source
Dexmedetomidine alleviatesmyocardial ischemia-reperfusion injury in rat models [PDF]
Jichu yixue yu linchuangObjective To investigate the relationship between the protective mechanism of dexmedetomidine (Dex) against myocardial ischemia-reperfusion(I/R) injury and cuproptosis.
LIU Genfeng, NAN Lu, GAO Qin, CHEN Yixuan, ZHANG Jing, YU Peng, YU Shuchun
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji +7 more
wiley +1 more source
Journal of Biomedical Science, 2011 Background Postconditioning (PostC) inhibits myocardial apoptosis after ischemia-reperfusion (I/R) injury. The JAK2-STAT3 pathway has anti-apoptotic effects and plays an essential role in the late protection of preconditioning. Our aim was to investigate
Liang Degang +5 more
doaj +1 more source