Results 161 to 170 of about 131,479 (353)

Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated the effects of histone lactylation on ferroptosis in hypoxia‐induced cardiomyocytes. A hypoxia model was established in AC16 cells treated with 2‐Deoxy‐D‐glucose (2‐DG, a glucose analogue), ferrostatin‐1 (Fer‐1, a selective ferroptosis inhibitor), lactate (LA), sh‐β‐catenin (shRNA of β‐catenin), or SKL2001 (an agonist ...
Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei Wang   +6 more
wiley   +1 more source

Imaging Ischemic and Reperfusion Injury in Acute Myocardial Infarction

, 2017
Jan Bogaert, Davide Curione, Pedro Morais, Manuel Barreiro‐Pérez, Sofie Tilborghs, Frederik Maes, Tom Dresselaers   +6 more
openalex   +2 more sources

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

Mechanisms by which silencing long-stranded noncoding RNA KCNQ1OT1 alleviates myocardial ischemia/reperfusion injury (MI/RI)-induced cardiac injury via miR-377-3p/HMOX1

BMC Cardiovascular Disorders
Background The key complication of myocardial infarction therapy is myocardial ischemia/reperfusion injury (MI/RI), and there is no effective treatment.
Tongcai Tan, Liang Tu, Yanmei Yu, MinJie He, Xingchao Zhou, Lei Yang   +5 more
doaj   +1 more source

Differential Regulation of mTOR Complexes with miR-302a Attenuates Myocardial Reperfusion Injury in Diabetes. [PDF]

iScience, 2020
Samidurai A, Ockaili R, Cain C, Roh SK, Filippone SM, Kraskauskas D, Kukreja RC, Das A.   +7 more
europepmc   +1 more source

Supplementary Material for: Expression of Plasma microRNA-1/21/ 208a/499 in Myocardial Ischemic Reperfusion Injury

, 2015
Wei Yang, Jiang Shao, X. Bai, Ge Zhang
openalex   +1 more source

e0016 Tongxinluo reduces myocardial ischaemia-reperfusion injury and no-reflow by stimulating the expression and phosphorylation of eNOS via PKA pathway [PDF]

, 2010
Xue Li, Yue Yang, Yong‐Jian Geng, Chunhua Jin, F.-H. Hu, Jinbo Zhao, H.-T. Zhang, Yang Cheng, Heying Qian, L.-L. Wang, Boli Zhang, Yechen Wu   +11 more
openalex   +1 more source

Validation of efficacy and mechanism of Sanwei-Tanxiang powder in improving myocardial ischemia reperfusion injuries [PDF]

, 2021
Yuhui Sun, Ren Bu, Yuewu Wang, Yuchong Hu, Xumei Wang, Xin Dong, Wen Zu, Yan Niu, Pengwei Zhao, Peng Sun, Shi‐Hang Ru, Jingkun Lu, Sheng-Sang Na   +12 more
openalex   +1 more source

Adding ROS Scavengers to Cold K\u3csup\u3e+\u3c/sup\u3e Cardioplegia Reduces Superoxide Emission During 2 h Global Cold Cardiac Ischemia [PDF]

, 2012
We reported that the combination of reactive oxygen species (ROS) quenchers Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), catalase, and glutathione (MCG) given before 2 hours cold ischemia better protected cardiac mitochondria against cold ...
Aldakkak, Mohammed, Camara, Amadou K.S., Heisner, James S., Riess, Matthias L., Stowe, David F.   +4 more
core   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source