Results 31 to 40 of about 68,817 (283)

Nanoparticle‐Mediated Simultaneous Targeting of Mitochondrial Injury and Inflammation Attenuates Myocardial Ischemia‐Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The opening of mitochondrial permeability transition pore and inflammation cooperatively progress myocardial ischemia‐reperfusion (IR) injury, which hampers therapeutic effects of primary reperfusion therapy for acute myocardial infarction. We
Gentaro Ikeda, Tetsuya Matoba, Ayako Ishikita, Kazuhiro Nagaoka, Kaku Nakano, Jun‐ichiro Koga, Hiroyuki Tsutsui, Kensuke Egashira   +7 more
doaj   +1 more source

Combined Right and Left Ventricular Reperfusion Injury Following Percutaneous Coronary Intervention: Role of Myocardial Contrast Echocardiography

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging, 2023
Right ventricular myocardial infarction (RVMI) occurs in up to half of the patients of inferior wall myocardial infarction. RVMI results in edema and increased right ventricular (RV) mass, and hence, it should be possible to visualize microvascular ...
Madhu Shukla, Jagdish Chander Mohan
doaj   +1 more source

The Safety and Efficacy of Intravascular Lithotripsy in the Treatment of Severe Coronary Artery Calcification in 261 Cases: A Retrospective Study

Health Science Reports
Background Coronary artery calcification is strongly linked to factors such as advanced age, dyslipidemia, and chronic kidney disease. Severe coronary artery calcification significantly elevates the complexity and risk of percutaneous coronary ...
Tiankun Wu, Honghui Yang, Guian Xu, Qingman Li, Lijie Zhu, Yapan Yang, Tingjie Yang   +6 more
doaj   +1 more source

Anaesthesia and myocardial ischaemia/reperfusion injury [PDF]

British Journal of Anaesthesia, 2009
Anaesthetists are confronted on a daily basis with patients with coronary artery disease, myocardial ischaemia, or both during the perioperative period. Therefore, prevention and ultimately adequate therapy of perioperative myocardial ischaemia and its consequences are the major challenges in current anaesthetic practice.
S. G. De Hert, J. Fräßdorf, Wolfgang Schlack   +2 more
openaire   +3 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury in experimental study and clinical practice

Zaporožskij Medicinskij Žurnal, 2019
Early reperfusion of the infarct related coronary artery is essential for the preservation of myocardial tissue and improve clinical outcome. The establishment of pharmacological and mechanical reperfusion treatment was a major improvement in the ...
S. M. Kozhukhov, O. M. Parkhomenko
doaj   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single‐center, open‐label, prospective study

Ibrain, EarlyView., 2023
Compound porcine perebroside and ganglioside injection (CPCGI) was used to treat ischemic stroke. However, there was no clinical evidence of low‐dose CPCGI. We conducted a clinical study to analyze whether the clinical results of low‐dose and standard‐dose CPCGI in patients with ischemic stroke were different.
Ya Chen, Xia Zhang, Hai‐Qing Zhang, Zhong Luo, Xue‐Jiao Zhou, Tao Liang, Fei Yang, Jun Zhang, Zu‐Cai Xu   +8 more
wiley   +1 more source

Iron imaging in myocardial infarction reperfusion injury [PDF]

Nature Communications, 2020
AbstractRestoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process.
Eileen Hwuang, Nicholas Josselyn, Felix W. Wehrli, Yuchi Han, Brianna F. Moon, William H. Matthai, Robert C. Gorman, Steffen Jockusch, Keitaro Okamoto, Joseph H. Gorman, Giovanni Ferrari, Avanti Gulhane, James J. Pilla, Anya T. Hall, Harold Litt, Srikant Kamesh Iyer, Andrew Tsourkas, Michael P. Solomon, Haochang Shou, Rishabh Kumar, Walter R Witschey, Akito Imai, Yoshiaki Saito, Samuel Keeney, Samuel Keeney, Estibaliz Castillero, Victor A. Ferrari, Cory M. Tschabrunn, Elizabeth Higbee-Dempsey   +28 more
openaire   +4 more sources