Results 191 to 200 of about 691,224 (357)

The mechanism of action of metabolic cytoprotector trimetazidine in acute ischemia-reperfusion injury

КардиоСоматика, 2014
The review presents, as the classical data on the mechanism of action of metabolic cytoprotector trimetazidine in acute ischemia/reperfusion injury associated with a partial inhibition of the oxidation of long chain fatty acids and increased metabolism ...
M. G Glezer, E. I Astashkin, M. V Novikova   +2 more
doaj  

Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis

Journal of Forensic Sciences, EarlyView.
Abstract The postmortem diagnosis of anaphylaxis remains a forensic challenge due to the lack of specific external signs. Tryptase, a mast cell‐derived protease, has emerged as a potential biomarker for fatal anaphylaxis. This systematic review critically examined 40 studies published between 2014 and 2024, including both biochemical and ...
Luca Tomassini, Giulia Ricchezze, Cristiana Gambelunghe, Massimo Lancia, Marco Gramaccia, Francesco De Micco, Piergiorgio Fedeli, Mariano Cingolani, Roberto Scendoni   +8 more
wiley   +1 more source

HSPA12B Protects Against Age‐Related Endothelial Cell Senescence by Regulating STING Degradation

Aging Cell, EarlyView.
Activation of the cGAS–STING pathway contributes to age‐related cardiac endothelial senescence, fibrotic remodeling, and functional decline. HSPA12B preserves endothelial homeostasis during aging by promoting XBP1‐dependent, SEL1L/HRD1‐mediated endoplasmic reticulum–associated degradation of STING, thereby attenuating cardiac endothelial senescence ...
Tingting Li, Peilin Zhu, Joseph Adams, Fei Tu, Jialing Wang, Chloe Garbe, Suman Dalal, Krishna Singh, Xiaojin Zhang, Li Liu, David L. Williams, Chuanfu Li, Xiaohui Wang   +12 more
wiley   +1 more source

Iatrogenic Myocardial Stunning: The After-Effects of Electrical Cardioversion. [PDF]

Cureus
Bhandari A, Rafique S, Oli PR, Murthy A.
europepmc   +1 more source

1149 Dobutamine stress echocardiography in patients with apical left ventricular ballooning syndrome for evaluation of myocardial stunning and dynamic intraventricular obstruction [PDF]

, 2005
Mario Previtali, Stefania Panigada, Lea Scuteri, E Baldini, Alessandra Repetto, Luigi Tavazzi   +5 more
openalex   +1 more source

miR‐140‐5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson‐Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway

Aging Cell, EarlyView.
This study identifies a novel molecular mechanism involving miR‐140‐5p that contributes to the pathogenesis of HGPS. By decreasing NRF2 expression, miR‐140‐5p overexpression results in downregulation of the NRF2/KEAP1/HO‐1 antioxidant pathway in HGPS fibroblasts, leading to increased oxidative stress and mitochondrial dysfunction, two hallmarks of ...
Léa Toury, Diane Frankel, Sara Nael, Mario Abaji, Léa Le Goff, Marie Basset, Coraline Airault, Bertrand Vernay, Elva María Novoa‐del‐Toro, Catherine Bartoli, Anaïs Baudot, Frederique Magdinier, Elise Kaspi, Patrice Roll   +13 more
wiley   +1 more source

Serious outcomes among emergency department patients with presyncope: A systematic review

Academic Emergency Medicine, EarlyView.
Abstract Background Syncope is transient loss of consciousness, and in presyncope, patients experience same prodromal symptoms without losing consciousness. While studies have extensively reported the risk of serious outcome among emergency department (ED) syncope, the outcome for patients with presyncope and their management are not well studied.
Hadi Mirfazaelian, Ian Stiell, Rasoul Masoomi, Khazar Garjani, Venkatesh Thiruganasambandamoorthy   +4 more
wiley   +1 more source

Effect of intradialytic exercise training on hemodialysis-induced myocardial stunning: a pilot-controlled trial. [PDF]

Clin Kidney J
Josse M, Patrier L, Cristol JP, Isnard M, Grandperrin A, Turc-Baron C, Nottin S, Mandigout S, Maufrais C, Obert P.   +9 more
europepmc   +1 more source

Safety and Efficacy Assessment of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2‐Positive Unresectable Locally Advanced or Metastatic Breast Cancer Previously Treated With Trastuzumab and a Taxane: An Open‐Label, Single‐Arm, Phase IV Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
A phase IV, single‐arm, open‐label, multicenter study assessing the safety and efficacy of trastuzumab emtansine in Indian patients for the treatment of human epidermal growth factor receptor 2 (HER2)‐positive unresectable locally advanced or metastatic breast cancer who received prior treatment with trastuzumab and a taxane.
Sudeep Gupta, Manish Singhal, Shona Nag, Waseem Abbas, Dinesh Chandra Doval, Hari Goyal, Chirag Shah, Ashish Singh, Radheshyam Naik, Nitesh Rohatgi, Poonam Patil, Shyam Aggarwal, Vinod Raina, Vaibhav Watts   +13 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source