Results 221 to 230 of about 103,145 (303)

Pimobendan alleviates myocyte apoptosis and fibrosis associated with mitral regurgitation by targeting endoplasmic reticulum stress. [PDF]

Animal Model Exp Med
Boonpala P, Tongta S, Saengklub N, Limprasutr V, Srikam S, Ji-Au W, Boonyarattanasoonthorn T, Panyasing Y, Kumphune S, Kalandakanond-Thongsong S, Kijtawornrat A.   +10 more
europepmc   +1 more source

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]

, 2017
et al,, Yee, Derek
core   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source

Diagnosis of rejection following heart transplantation: diving into the future. [PDF]

Front Transplant
Rao S, Ali SZ, Singh A, Rana M, Moussa M, Ahmed K, Golob S, Cusumano L, Harrington A, Wang A, Chandrasekhar S, Alam A.   +11 more
europepmc   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

β-Adrenergic Receptors: Not Always Outside-In. [PDF]

Physiology (Bethesda)
Dodge-Kafka KL, Turcotte MG, Possidento SM, Kapiloff MS.   +3 more
europepmc   +1 more source

Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure

The Journal of Physiology, EarlyView.
Abstract figure legend Impact of Omecamtiv Mecarbil (OM) on in‐silico models of heart failure. A mathematical electromechanical model of human ventricular tissue is used to simulate the effects of OM in heart failure with reduced ejection fraction (HFrEF).
Maria Teresa Mora, Ilse van Herck, Cécile Daversin‐Catty, Henrik Finsberg, Jordi Llopis‐Lorente, Javier Saiz, Hermenegild Arevalo, Samuel Wall, Beatriz Trenor   +8 more
wiley   +1 more source

Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy. [PDF]

Science
Bretherton RC, Reichardt IM, Zabrecky KA, Nagle A, Bailey LRJ, Bugg D, Smolgovsky S, Gifford AL, McMillen TS, Goldstein AJ, Kooiker KB, Flint GV, Martinson A, Gunaje J, Koser F, Plaster E, Linke WA, Regnier M, Moussavi-Harami F, Sniadecki NJ, DeForest CA, Davis J.   +21 more
europepmc   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Differentially expressed fusogens specify myocyte states to drive myogenesis. [PDF]

Development
Nahlé S, Javed A, Joumier L, Kherdjemil Y, Sitolle J, Khetchoumian K, Parekh Y, Krezel W, Malleshaiah M, Le Grand F, Cayouette M, Côté JF.   +11 more
europepmc   +1 more source